Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case Report
© Bitchatchi et al; licensee BioMed Central Ltd. 2010
Received: 17 November 2010
Accepted: 16 December 2010
Published: 16 December 2010
A 27-year-old female white-collar worker was diagnosed in 1998 with mesothelioma eight and one-half years following first exposure as a bystander to debris in a site in which asbestos-containing building materials were being dismantled and rebuilding work took place. Prodromal back pain had been present for a year and a half. She underwent extrapleural pneumectomy and received an intrapleural infusion of cisplatin post-operatively. Exposure to asbestos was verified by contemporary reports and lung biopsy, which demonstrated asbestos bodies and microscopic interstitial fibrosis -conforming evidence for asbestosis. The patient is alive and well 12 years after diagnosis and 14 years after onset of symptoms. The combination of an extremely short latency period and long survival following occupational exposure to asbestos dust is unique.
The patient recalled her first exposure to dusts during intensive demolition/construction work at her workplace, an airport office. The work--the first job in her life, when drafted into the military-- began in 1989 when she was 20 years of age, and continued for approximately 6 years. Co-workers under judicial investigation recalled seeing asbestos wallboard and debris at the site. Her work routine included excessive work hours, sleeping on site and irregular work shifts (approximately 5000 hours of passive, intermittent, exposure to airborne dust). During the 4th calendar year, she became pregnant and got post labor permission for 3 months. No measurements of concentrations of asbestos, constituents of environmental tobacco smoke, man-made-vitreous-fibers and respirable particulate, dusts or gasses were carried out. Information was not available on the mix of fibers in the dusts during demolition at her work site. However, a newspaper article in 1989, contemporary with exposure, reported that Dr Joseph Ribak, then chief of occupational medicine of the major national health care provider, specified that her work site was one of several with acoustic ceilings sprayed with asbestos fibers . We also know that in Israel, the fiber mix of most asbestos construction products was approximately 90% chrysotile -10% amphiboles .
The patient's past exposure history was otherwise unremarkable, with negative answers to directed questions on exposures as bystanders to asbestos or talc in family, work, home, or hobbies. Her father worked as a police officer and her mother as a housewife, partially self-employed in sewing jobs. No other working adult lived in the household. Based on an official list of all her past addresses, we double-checked those obtained by detailed anamnesis confirming no history of residency near asbestos cement plants or brake lining plants from infancy onward. She denied having contact with Thorotrast.
To the best of our knowledge, the seven-year latency period between first exposure and complaints, and 8.5 years (14 months lapsed between symptoms and diagnosis) to diagnosis of mesothelioma is the shortest ever reported in an adult. The case for this conclusion rests on both tissular and independent ascertainment of exposure, notably the contemporary report by occupational health authorities specifically referring to asbestos dust exposures at the patient's workplace. The light microscopy technique, with a 60× objective lens is too low a magnification to detect the vast majority of asbestos fibers retained. The moderately elevated concentration above background -in the patient's resected lung is supportive of her past work exposures causing mesothelioma [6–13], given the absence of any other known source. The finding of asbestosis is a strong confirmation that she had substantial asbestos exposure.
We note that the demonstration of several asbestos bodies in a light micrograph of lung tissue when combined with interstitial fibrosis on histology is sufficient also for a diagnosis of asbestosis using standard NIOSH/College of American Pathology criteria . Her unilateral imaging features are not in agreement with pulmonary fibrosis as set by current criteria. However, histologically proved asbestosis has been recognized elsewhere, despite lack of abnormalities on a CT scan . Our case represents indeed a deviant from common acceptance of an incubation of tens of years to diagnosis of this pneumoconiosis [15, 16], with a minimum latency of 10 years . The occupational history and the discovery of asbestos facts in conjunction with the histopathologic detection of interstitial fibrosis make the hypothesis for a "spontaneous case" for mesothelioma most unlikely.
Davis and Rall published a table, which specified that the latent period for cancer in persons with workplace exposures to high volume carcinogens can range from 4 to 40 years . A study from Poland reported 16 cases of pleural mesothelioma found among a cohort exposed from 1987 to 1997. Four of the patients were employed for periods ranging from 3.5 months to five years. Two of the four had latency periods of 11-12 years from onset of occupational exposure. These four patients had occupational and prior residential exposures associated with massive use of commonly available asbestos-cement wastes as road surface material . Our report along with that from Poland calls into question the general consensus that latencies for mesothelioma under 10 years are improbable.
An absence of calcified pleural plaques in our patient may imply shorter latency since exposure [20, 21]. Animal experiments with implantation of asbestos or other fibers in the pleura or peritoneum show that the latent period shortens as fiber dose is increased and lengthens as the dose of fiber is reduced . The present report indicates that high prior exposures, particularly at younger ages, may result in shortened induction periods, in keeping with classic observations on increased dose and shortened latency [22–24].
Individuals with direct exposures associated with the construction trades are apt to be the most heavily exposed . During pregnancy, the physiological augmentation of minute ventilation leads to a greater dust burden into lung parenchyma. As with ionizing radiation, the earlier the age at exposure, the shorter the latency period for asbestos related cancers . Worker cohort studies indicate that earlier age of exposure predicts incremental lifelong adjusted risks for mesothelioma [27, 28] and persons near asbestos work are at risk of "bystander exposure" [29, 30].
This patient was diagnosed with asbestosis and mesothelioma eight and one-half years following asbestos exposure independently reported at the time of its occurrence. She has survived twelve years post diagnosis and resection. Although unexpected longevity has been reported elsewhere [33, 34], we have no explanation for the long survival despite the very short latency.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
National Institute for Occupational Health and Safety
College of American Pathologists, Other abbreviations were defined in the text.
The authors thank Alf Fischbein and Arthur L. Frank for their advice and encouragement.
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