Intravascular large B-cell lymphoma of the kidney: A case report
© Bai et al; licensee BioMed Central Ltd. 2011
Received: 28 June 2011
Accepted: 23 September 2011
Published: 23 September 2011
We report a 41-year-old Chinese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy. The patient was admitted to Nanfang Hospital of Southern Medical University, Guangzhou, China with complaints of high spiking fever for a month and bilateral lower limb fatigue with difficulty ambulating for the past 5 months.
She had renal dysfunction with a total urinary protein of 5.61 g/dL (56.1 g/L), serum albumin of 2.89 g/dL (28.9 g/L), urea nitrogen of 2.24 mg/dL (1.6 mmol/L), and serum creatinine of 0.54 mg/dL (48 μmol/L). Bone marrow biopsy revealed myeloproliferative disorder without abnormal myeloid or lymphocytic proliferation. Positron Emission Tomography-Computed Tomography (PET-CT) showed marked bilateral swelling and enlargement of the renal parenchyma with splenic enlargement and involvement of multiple vertebrae. Percutaneous renal biopsy showed island-like accumulations of medium to large lymphoid cells in many areas of the interstitium, with round vesicular nuclei containing distinct basophilic nucleoli. Immunohistochemical analysis together with other supportive investigation confirmed the diagnosis of intravascular large B-cell lymphoma. Ten days later, she was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, leurocristime and prednisone) for a week. Palliative radiotherapy DT 40Gy/20F with other supportive treatment was provided for metastatic foci in the medullary cavity of the sternum, T1-T7. The patient regained muscle strength in both lower limbs and was able to walk again after three weeks. The patient was discharged after hepatic and renal function and proteinuria values had returned to normal. Follow-up data shows the patient to be alive nine months after discharge.
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KeywordsKidney Intravascular large B-cell lymphoma Renal biopsy
Intravascular large B-cell lymphoma (IVLBCL) is a rare variant of large B-cell lymphoma characterized by proliferation of malignant lymphoid cells in small vessels of organs such as skin, kidneys, adrenals, lungs, liver and the central nervous system. Neurologic findings and skin manifestations may present a clue clinically, while fever of unknown origin without weight loss is a common non-specific symptom. Since Jothy et al first reported a case of IVLBCL in kidney in 1981 , seventeen additional cases have been published in the literature [2, 3]. Most of these cases had malignant lymphoid cells localized within the glomerular capillaries. One case reported the localization of lymphoma cells within peritubular capillaries .
We report here a case with markedly enlarged kidney showing clustering of lymphoma cells within the peritubular capillaries.
A 41-year-old Chinese woman was referred to the Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, China, with the chief complaint of high spiking fever for approximately a month with bilateral lower limb fatigue and difficulty in defecation for more than five months. She had been residing in Yingde City of Guangdong Province for 10 years with no known prior exposure to any infectious or occupational diseases. In July 2010, she was diagnosed with 'whole body multiple metastases of lymphoma'. Due to economic reasons, the patient was transferred at the end of July 2010 to Donghua Hospital of Yingde City for treatment of her symptoms of infection, constipation, low potassium and leukopenia. By August 2010, the patient was unable to walk with bilateral lower limb fatigue and was subsequently admitted to the Department of Radiation Oncology at Nanfang Hospital.
On admission, the patient was 152 cm tall and weighed 52 kg. Her blood pressure was 112/82 mm Hg, temperature 38.5°C with a respiratory rate of 16 times per minute. No superficial enlarged lymph nodes were palpable. Inspiratory and expiratory sounds were normal to auscultation. There was no percussion tenderness over the liver or kidney. Muscle strength of upper limbs was normal and that of lower limbs was 3/5. Bilateral Babinski sign was positive. Sensation of pain and touch below the knees were slightly reduced. Physiological reflexes were slightly active. There was no pedal edema. All other physical tests were normal.
Laboratory findings were as follows: total urinary protein, 5.61 g/dL (56.1 g/L); serum albumin, 2.89 g/dL (28.9 g/L); blood urea nitrogen, 2.24 mg/dL (1.6 mmol/L); and creatinine, 0.54 mg/dL (48 μmol/L). The urine protein and occult blood values were negative. Urinary leukocyte count was 48/μL (4.8 × 107/L); erythrocyte count, 3.78 × 106/μL (3.78T/L); hemoglobin, 9.9 g/dL (99 g/L); lymphocyte count, 1.12 × 103/μL (1.12 g/l) and platelet count, 1.73 × 105/μL (173 g/l).
Pathologic examinations of percutaneous renal biopsies confirmed the diagnosis of intravascular large B-cell lymphoma of Stage IVE. The patient returned to the local hospital for symptomatic treatment after diagnosis. Ten days later she was readmitted into Nanfang hospital due to sudden bilateral lower limb fatigue and inability to walk. She was treated with chemotherapy consisting of CHOP (cyclophosphamide 1.0 g D1+Doxorubicin 60 mg D1+leurocristime 2 mg D1+Prednisone 100 mg D1-5) for a week. Palliative radiotherapy DT 40Gy/20F and other supportive treatment were provided for metastatic foci in the medullary cavity of sternum, T1-7. The patient regained muscle strength in both lower limbs and was able to walk again. She was discharged after hepatic and renal function values had returned to normal. Follow-up data shows the patient to be alive, nine months after discharge.
Intravascular Large B-cell Lymphoma (IVLBCL), also described as intravascular lymphomatosis, angiotropic large cell lymphoma, and malignant angioendotheliomatosis, is a very rare subtype of Non-Hodgkin's lymphoma. The true incidence is unknown and there is no known sex predilection. The prognosis is usually very poor despite use of chemotherapy. Most patients present with fever of unknown origin and nonspecific cutaneous and neurologic manifestations. The renal involvement with IVLBCL has been classified as either intraglomerular growth or tubulointerstitial invasion. Microscopically, it is characterized by the proliferation and infiltration of lymphoma cells in capillaries and venules. No obvious extravascular tumor mass or detectable circulating tumor cells are observed in the peripheral blood.
The clinical manifestations include symptoms related to multi-organ failure . In the past, the diagnosis was usually made at autopsy. With increased awareness and improved physical health check-ups more cases have been detected during life allowing for active and effective treatment.
The first case with IVLBCL was diagnosed by renal biopsy in 1981 . Since then, several other studies have reported similar cases [6–8]. The common pathologic finding is localization of the lymphoma cells within the lumina of the glomerular capillaries. Bilateral marked nephromegaly is the other major clinical feature in patients with the tubulointerstitial type of disease. Renal size has been reported to improve rapidly in response to chemotherapy. Clinical findings associated with IVLBCL are reported to be acute renal failure (ARF) and nephritic-range proteinuria. The ARF might be caused by the obstruction of glomerular circulation due to the invasion of the lymphoid cells, as has been suggested in acute proliferative glomerulonephritis, resulting in a loss of renal function. The greater the proportion of glomeruli that is affected by the infiltration of tumor cells, the more the renal function has deteriorated, consistent with the view that the presence of tumor cells impair glomerular function. In the IVLBCL cases with nephrotic range proteinuria, histology of renal biopsies revealed minimal glomerular lesions because of the absence of immune deposits in the glomeruli.
In the present case, lymphoma cells involved multiple loci including the kidney, skeletal system, lungs, lymph nodes, spleen, and pelvic cavity. The mechanism of renal dysfunction could be due to the obstruction of peritubular capillaries with increased post glomerular vascular resistance, compression of tubules, or modulation of the tubuloglomerular feedback mechanism. The impairment of the patient's skeletal and pulmonary systems resulted in movement dysfunction and interstitial pneumonia. Lymph node inflammatory proliferation is considered with multiple bilateral neck and mediastinum lymph nodes enlargement. This indicates the occlusion of lymphoma cells in the vasculature, causing thrombosis and multiple system dysfunctions . The enlarged lymph nodes may block drainage of fluid that lubricates the pelvic cavity, causing effusion accumulations and symptoms such as lower limb edema, pelvic effusion, and anorexia.
In the present case, the tumor cell accumulation is demonstrated to be confined within the peritubular capillary walls, by anti-CD34 staining. These lymphoid cells are positive for B-cell markers CD20, CD79a, and PAX-5. They are also positive for mum-1 and bcl-6, suggesting origin from the active B lymphocyte. The immunohistochemical analysis confirmed the diagnosis of IVLBCL. Although the cause for highly selective peritubular capillary localization of the lymphoma cell is unclear, it is possible the large size of the lymphoma cell results in entrapment of tumor cells within the glomerular rather than peritubular capillaries. The examination of the bone marrow was not helpful in the diagnosis of this case unlike other cases reported in literature .
In conclusion, when tubulointerstitial cell infiltration is found in a patient with bilateral marked nephromegaly and renal dysfunction without proteinuria, intra-peritubular capillary lymphoma should be considered as a possible diagnosis.
Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
List of abbreviations
Acute renal failure was abbreviated
Intravascular large B-cell lymphoma
Positron Emission Tomography-Computed Tomography
We thank Dr. Susanne Nicholas from Ronald Reagan UCLA Medical Center and John Basgen from Charles Drew School of Medicine and Science for the critical readings of the manuscript. This study was supported by grants from National Natural Science Foundation of China (Grant No: 81100496) and the Science and Technology Planning Project of Guangdong Province, P R China (Grant No: 2008B010600042).
- Jothy S, Knaack J, Onerheim RM, Barre PE: Renal involvement in malignant histiocytosis. An immunoperoxidase marker study. Am J Clin Pathol. 1981, 76: 183-189.PubMedGoogle Scholar
- Yoo J, Kuppachi S, Chander P: Quiz page. Large B-cell lymphoma, intravascular type, with diffuse glomerular and focal interstitial infiltration. Am J Kidney Dis. 2008, 51: A43-46.View ArticlePubMedGoogle Scholar
- Kameoka Y, Takahashi N, Komatsuda A, Tagawa H, Hamai K, Hirokawa M, Wakui H, Ichinohasama R, Sawada K: Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL?. Int J Hematol. 2009, 89: 533-537. 10.1007/s12185-009-0294-5.View ArticlePubMedGoogle Scholar
- Sawa N, Ubara Y, Katori H, Hoshino J, Suwabe T, Tagami T, Takemoto F, Miyakoshi S, Taniguchi S, Ohashi K, Takaichi K: Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case. Intern Med. 2007, 46: 657-662. 10.2169/internalmedicine.46.6333.View ArticlePubMedGoogle Scholar
- Nakashima MO, Roy DB, Nagamine M, Roullet MR, Gabriel CA, Sood SL, Bagg A: Intravascular large B-cell lymphoma: a mimicker of many maladies and a difficult and often delayed diagnosis. J Clin Oncol. 2011, 29: e138-140. 10.1200/JCO.2010.31.5408.View ArticlePubMedGoogle Scholar
- Masaki Y, Miki M, Sakai T, Sawaki T, Fukushima T, Umehara H: [Intravascular large B-cell lymphoma: an important cause of fever of unknown origin]. Brain Nerve. 2011, 63: 435-441.PubMedGoogle Scholar
- Hishikawa N, Niwa H, Hara T, Hara K, Ito M, Shimada S, Yoshida M, Hashizume Y, Murakami N: An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs. Neuropathology. 2011Google Scholar
- Park JH, Lee DY, Ko YH: Intravascular large B-cell lymphoma of the cutaneous variant in Korea. J Dermatol. 2011, 38: 160-163. 10.1111/j.1346-8138.2010.01100.x.View ArticlePubMedGoogle Scholar
- Yasuda H, Ando J, Matsumoto T, Ogura K, Ozaki Y, Aritaka N, Aoki Y, Sugita M, Nomura T, Sekii H, Yamaguchi N, Iguchi S, Yamamoto T, Komatsu N, Hirano T: Intravascular large B cell lymphoma with hepatic portal vein, splenic vein and mesenteric vein tumour embolism. Histopathology. 2010, 57: 648-650. 10.1111/j.1365-2559.2010.03660.x.View ArticlePubMedGoogle Scholar
- Ferreri AJ, Campo E, Seymour JF, Willemze R, Ilariucci F, Ambrosetti A, Zucca E, Rossi G, Lopez-Guillermo A, Pavlovsky MA, Geerts ML, Candoni A, Lestani M, Asioli S, Milani M, Piris MA, Pileri S, Facchetti F, Cavalli F, Ponzoni M: Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'. Br J Haematol. 2004, 127: 173-183. 10.1111/j.1365-2141.2004.05177.x.View ArticlePubMedGoogle Scholar
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