Dendritic fibromyxolipoma in the right inguinal and perineum regions: a case report and review of the literature
© Zhang et al.; licensee BioMed Central Ltd. 2013
Received: 7 July 2013
Accepted: 29 August 2013
Published: 20 September 2013
A 32-year-old woman presented with a slow-growing, painless, subcutaneous lesion in the right inguinal and perineum regions. The mass was 24.0 cm × 10.5 cm × 5.0 cm in size, well circumscribed, mobile, and rubbery. Microscopically, the resected mass was mainly composed by a proliferation of small spindle or stellate cells, variably admixed with mature adipose tissue, embedded within an abundant myxoid and collagenized stroma. Immunohistochemically, the spindle and stellate cells were strongly positive for vimentin, CD34, and bcl-2 antibodies but not for smooth muscle actin and desmin. The tumor was diagnosed as dendritic fibromyxolipoma based on the typical findings of histology and immunohistochemistry. Clinical follow-up of 9 months after surgery revealed no evidence of recurrence. We report the first case of dendritic fibromyxolipoma in the right inguinal and perineum regions and discuss the different diagnosis.
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KeywordsDentritic fibromyxolipoma The inguinal region The perineum region
Dendritic fibromyxolipoma (DFML) is a rare benign soft tissue lesion that most commonly arises in the subcutis or muscular fascia of the head and neck, shoulders, calf, foot, or back in adult male patients. The characteristic histologic picture is described as an admixture of mature adipose tissue, spindle and stellate cells, and abundant myxoid stroma with prominent collagenization. These neoplasms typically show positive immunoreactivity for CD-34, bcl-2 and Vimentim. We describe a case of DFML in the right inguinal and perineum regions. To our best knowledge, female DFML in inguinal including the perineum region has not been reported.
Clinical findings of DFML in the 15 patients reported in the Einglish literature
Location size (cm)
11-cm mass in left posterior shoulder acromium region
7.5 × 5.5 × 3.0 cm, right shoulder
NED, 7 year
5.0 × 5.0 × 4.0 cm, right posterior neck
6.0 × 5.5 × 2.0 cm, upper back
8.0 × 3.5 × 2.5 cm, back of the neck
9.0 × 7.0 × 6.5 cm, back, posterior axillary fold
2.0 × 2.0 × 2.0 cm, face right nasal area
NED, 11 year
7.0 × 5.5 × 2.5 cm, right posterior neck
NED, 13 year
3.0 × 2.0 × 1.5 cm, back of neck
NED, 5 year
3.5 × 3.0 × 2.5 cm, right chest wall
Died of meta static Carcinoma of giant cell carcinoma of the Lung 2 year after surgery
3.5 × 3.0 × 3.0 cm, left chest wall, infraclavicula
NED, 5 year
6.0 × 5.5 × 5.0 cm, right upper back
13.0 × 8.0 × 5.5 cm, between the infraspinatus and deltoid muscles
NED, 8 mouths
CD34+, BCL-2 +
The median nerve in the left forearm
CD34+, BCL-2 +
2.0 × 2.0 × 2.0 cm
NED, 2 years
in the lower lip
The most striking histologic feature of DFML is an admixture of mature adipose tissue, spindle and stellate cells, and abundant myxoid stroma with prominent collagenization. Immunohistochemically, the vimentin and CD34 immunohistochemical stains accentuated the cell’s dendritic nature by revealing slender, complex cytoplasmic prolongations which are the main reason of it’s named . The curative treatment for DFML is completely local excision. Recurrence or metastasis has never been reported in DFML patients after surgical treatment.
DFML should be differentiated from some benign lesions: spindle cell lipoma (SCL), solitary fibrous tumor(SFT), lipoblastoma, lipoblastomatosis, and nodular fascitis. Of the other tumor-like lesions, SCL is most likely to be confused with DFML. SCL is composed of a mixture of mature adipocytes and uniform spindle cells within a matrix of mucinous material traversed by a varying number of birefringent collagen fibers. It shares many features with DFML including age, male predilection, location, gross features. The signally similar clinical and histological feature of the lesions makes it difficult for distinguishing DFML from SCL . Suster et al. emphasized the dendritic nature of the spindle cells, the plexiform vascular pattern, and the abundance of keloidal collagen as the three essential features in DFML, which were not commonly presented in SCL . But recently studies revealed that some features, such as prominent vascular patterns, and short bipolar cytoplasmic extensions, also had been seen in SCL .
Other benign spindle cell tumor that should be distinguished from DFML is solitary fibrous tumor (SFT). SFTs which have a predilection for the thoracic cavity are rare fibrous neoplasms. Histologically, the tumor is characterized by a “patternless pattern” of short spindle cells with scant cytoplasm and bland cytologic appearance separated by strands of rope-like collagen, and a “hemangiopericytoma-like” pattern where the lesional cells are densest around small and medium ectatic and branching vessels . The “hemangiopericytoma-like” vascular pattern and the lack of an adipose tissue component are two histologically features for distinguishing SFT from DFML . Lipoblastoma and lipoblastomatosis are another two rare benign soft tissue mesenchymal tumours that may be confused with DFML. The tumours mainly occur almost exclusively in infants and children under the age of 3 years. The common microscopic features of lipoblastoma and lipoblastomatosis have been described as a mixture composed of immature lipoblasts,mature lipocytes,embedded in an abundant myxoid stroma. DFML could be easily distinguished from lipoblastoma and lipoblastomatosis by the patients age and the absence of lipoblasts [1, 7]. Nodular fascitis is another lesion that should be differentiated from DFML. Nodular fascitis shows proliferating spindle cells embedded in a loosely textured myxoid and inflammatory stroma. Unlike DFML, the lesion is relatively well circumscribed but poor encapsulated. Immunohistochemically, the spindle cells are positive for muscle markers except desmin and are S-100 protein and CD-34 negative .
The distinction between DFML and malignancy, both of which can have a plentiful myxoid matrix, proliferation of capillaries and relatively large size, is more subtle and difficult. Among the malignant tumors, the possibility of a myxoid liposarcoma (MLS) should be seriously considered. MLS, a low grade malignancies, is the most common subtype of liposarcoma. MLS shares many features with DFML including a delicate plexiform vascular pattern, large size, and a myxoid matrix. But MLS is distinguished from DFML by the lower extremities fascial planes predilection, the infiltration of surrounding structures, and the presence of lipoblasts on higher magnification [1, 9]. Furthermore, molecular studies had shown that MLS was characterized by the recurrent translocations t(12;16)(q13;p11) and, less commonly, t(12;22)(q13;q12), which fuse FUS or EWSR1, respectively, to DDIT3 on chromosome 12 gene . Narendra et al. confirmed that FISH with DDIT 3 break-apart probe was a valuable adjunct in diagnosis or differential diagnosis of MLS .
DFML has never been described in the perineum region. DFML in the perineum region of females should be differentiated from perianal sepsis, lesions of anogenital mammary-like glands (AGMLG) and some relatively site-specific stromal tumours. Perianal abscess/sepsis is the most common cause of a mass in the perineum region and can be easily differentiated from DFML by its clinical presentation . AGMLG are a newly recognized variant of cutaneous adnexal glands that are found in the anogenital area of both sexes, with characteristics of modified eccrine and apocrine glands. Lesions of AGMLG such as hidroadenoma papilliferum, apocrine cystadenoma, adenosis tumor, and extramammary Paget's diasease, show a typically striking homology with lesions in the breast. Histologically, the appearance of glandular structures and the histological homology to its counterpart breast lesions, helps distinguish lesions of AGMLG from DFML . Some stromal tumours, including angiomyofibroblastoma, aggressive angiomyxoma, cellular angiofibroma, leiomyosarcoma, rhabdomyosarcoma and epithelioid sarcoma, can also be found in the perineum region [14, 15]. Of these, angiomyofibroblastoma, aggressive angiomyxoma, leiomyosarcoma, rhabdomyosarcoma and epithelioid sarcoma can be easily distinguished from DFML by their histopathological and immunohistochemical findings. The distinction between DFML and cellular angiofibroma, both of which can have adipocytes in addition to the characteristic vascular network and connective tissue stroma, is more subtle and difficult. However, cellular angiofibroma lacks the dendritic processes and prominent myxoid component of DFML. In addition, the striking hyalinization of the blood vessel walls in cellular angiofibroma is another distinctive feature not found in DFML [2, 16].
Even though DFML has been found for more than 14 years, the nosological position of DFML is still indeterminate. Suster et al.  initially stressed that DFML represented a transitional form between SCL and SFT. But recently studies by Fritchie et al.  on the molecular relationship with SCL and SFT had found that only SCL showed monoallelic or biallelic loss of 13q14(RB1), revealed that SCL had not relationship with SFT. Karim et al.  thought that DFML probably represents an peculiarly variant of myxoid SCL, based on their similarly clinical and pathological features.
Dendritic fibromyxolipoma is very rare benign tumor. We report the first example of DFML in the right inguinal and perineum region. A diagnosis of DFML should be made by their microscopical and immunohistochemical features. DFML should be considered in the differenial diagnosis of lesions with spindle cell lipoma, solitary fibrous tumor, lipoblastoma, lipoblastomatosis, nodular fasciitis, and myxoid liposarcoma.
Written informed consent was obtained from patient's parents for publication of this case report and any accompanying images.
- Suster S, Fisher C, Moran CA: Dendritic fibromyxolipoma: clinicopathological study of adistinctive benign soft tissue lesion that may be mistaken for a sarcoma. Ann Diagnostic Pathol. 1998, 2: 111-120. 10.1016/S1092-9134(98)80047-6.View ArticleGoogle Scholar
- Karim RZ, McCarthy SW, Palmer AA, Bonar SF, Scolyer RA: Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma?. Pathol Int. 2003, 53: 252-258. 10.1046/j.1320-5463.2003.01464.x.View ArticlePubMedGoogle Scholar
- Dahlin LB, Ljungberg O: Dendritic fibromyxolipoma adherent to the median nerve in the foream. J Plast Surg Hand Surg. 2012, 46: 120-123. 10.3109/02844311.2010.503083.View ArticlePubMedGoogle Scholar
- Al-Maskery AY, Al-Sidairy SM, Al-Hamadani AS: Dendritic Myxofibrolipoma: often misdiagnosed as sarcoma. Craniomaxillofac trauma Reconstr. 2011, 4: 171-174. 10.1055/s-0031-1286122.PubMed CentralView ArticlePubMedGoogle Scholar
- Fletcher CDM, Martin-Bates E: Spindle cell lipoma: a clinicopathological study with some originalobservations. Histopathology. 1987, 11: 803-817. 10.1111/j.1365-2559.1987.tb01884.x.View ArticlePubMedGoogle Scholar
- Suster S, Nascimento AG, Miettinen M, Sickel JZ, Moran CA: Solitary fibrous tumors of softtissue. A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol. 1995, 19: 1257-1266. 10.1097/00000478-199511000-00005.View ArticlePubMedGoogle Scholar
- Bourelle S, Viehweger E, Launay F, Quilichini B, Bouvier C, Hagemeijer A, Jouve JL, Bollini G: lipoblastoma and lipoblastomatosis. J Pediatr Orthop B. 2006, 15: 356-361. 10.1097/01202412-200609000-00010.View ArticlePubMedGoogle Scholar
- Squillaci S, Tallarigo F, Patarino R, Bisceglia M: Nodular fasciitis of the male breast: a case report. Int J Surg Pathol. 2007, 15: 69-72. 10.1177/1066896906295999.View ArticlePubMedGoogle Scholar
- Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG: The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer. 1996, 77: 1450-1458. 10.1002/(SICI)1097-0142(19960415)77:8<1450::AID-CNCR5>3.0.CO;2-G.View ArticlePubMedGoogle Scholar
- Powers MP, Wang WL, Hernandez VS, Patel KS, Lev DC, Lazar AJ, López-Terrada DH: Detection of myxoid liposarcoma-associated FUS–DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay. Mod Pathol. 2010, 23: 1307-1315. 10.1038/modpathol.2010.118.View ArticlePubMedGoogle Scholar
- Narendra S, Valente A, Tull J, Zhang S: DDIT3 gene break-apart as a molecular marker for diagnosis of myxoid liposarcoma--assay validation and clinical experience. Diagn Mol pathol. 2011, 20: 218-224. 10.1097/PDM.0b013e3182107eb9.View ArticlePubMedGoogle Scholar
- Hill DA, Dehner LP, Gow KW, Pappo AS, Crawford D, Pflaumer SM, Furma WL, Hayes-Jordan AA, McDermott MB: Perianal Rhabdomyosarcoma Presenting as a Perirectal Abscess: A Report of 11 Cases. J Pediatr Surg. 2002, 37: 576-581. 10.1053/jpsu.2002.31613.View ArticlePubMedGoogle Scholar
- Hatanaka K, Tanimoto A, Umekita Y, Yoshioka T, Kanekura T: Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. Diagn Pathol. 2010, 5: 42-10.1186/1746-1596-5-42.PubMed CentralView ArticlePubMedGoogle Scholar
- Behranwala KA, Clark MA, Thomas JM: Soft-tissue tumours of the perineum. Eur J Surg Oncol. 2002, 28: 437-442. 10.1053/ejso.2002.1267.View ArticlePubMedGoogle Scholar
- Grobmyer SR, Clary B, Lewis JJ, Delgado R, Woodruff JM, Brennan MF: Adult Perineal Sarcomas. J Surg Oncol. 2001, 77: 101-104. 10.1002/jso.1078.View ArticlePubMedGoogle Scholar
- Nucci MR, Granter SR, Fletcher CD: Cellular Angiofibroma: A Benign Neoplasm Distinct from Angiomyofibroblastoma and Spindle Cell Lipoma. Am J Surg Pathol. 1997, 21: 636-644. 10.1097/00000478-199706000-00002.View ArticlePubMedGoogle Scholar
- Fritchie KJ, Carver P, Sun Y, Batiouchko G, Billings SD, Rubin BP, Tubbs RR, Goldblum JR: Solitary fibrous tumor: is there a molecular relationship with cellular angiofibroma, spindle cell lipoma, andmammary-type myofibroblastoma?. Am J Clin Pathol. 2012, 137: 963-970. 10.1309/AJCPQEG6YNN6CNAL.View ArticlePubMedGoogle Scholar
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