Retroperitoneal paraganglioma with metastasis to the abdominal vertebra: a case report
© He et al.; licensee BioMed Central Ltd. 2013
Received: 28 December 2012
Accepted: 10 March 2013
Published: 28 March 2013
Extra-adrenal paraganglioma of the retroperitoneum with metastasis to the vertebra is very rare. To our knowledge this is the first report of this kind of disease in the literature.
Here, we present an oroginal case of paraganglioma of the retroperitoneum with metastasis to the abdominal vertebra in a 42-year-old female patient who was successfully treated by complete removal of the tumor and its metastasis. The patient was followed up for four years and remained disease-free.
Our case demonstrated the need to consider paraganglioma of the retroperitoneum in the differential diagnosis of retroperitoneal mass, metastatic tumors to the vertebra, and the importance of radical surgery for a successful management of the disease.
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KeywordsParaganglioma Retroperitoneum Metastasis Vertebra
Paragangliomas, also known as extra-adrenal pheochromocytomas, are rare neuroendocrine neoplasms that are derived from the paraganglia, a diffuse neuroendocrine system dispersed from the skull base to the pelvic floor. They are found in many tissues such as the adrenal medulla, the carotid bodies, the organs of Zuckerkandl, and the paraganglia of the sympathetic and parasympathetic neurons [1, 2]. Paragangliomas usually occur in the head and neck region but rare in the retroperitoneum. It has been estimated that as much as 10% paragangliomas of the retroperitoneum arise outside of the adrenal gland. In addition, few cases regarding paragangliomas of the retroperitoneum with metastases have been reported .
After two weeks, the patient was transferred to the Department of Spine Surgery for resection of the lumbar tumor and treated by posterior fixation with Moss Miami system (Figure 2D, 2E, 2F). Intraoperative blood loss is 3000 ml. Pathological examination showed metastasis of the paraganglioma to the vertebra. The patient has been followed up for four years and does not show any sign of recurrence (Figure 1D2).
The clinical, pathologic and radiological features of retroperitoneal paragangliomas have been previously described [4, 5]. Paraganglioma can be diagnosed in early stage if it is a functional tumor secreting excessive amounts of catecholamine. For those patients with a nonfunctional paraganglioma, VMA and catecholamine are normal in her urine and blood. Diagnosis of retroperitoneal paraganglioma could be delayed as it usually relies on the growth of the tumor mass. It is hard to make a correct preoperative diagnosis due to absence of typical clinical symptoms in the patient.
CT, MRI or ultrasonographic studies are sensitive in detecting a retroperitoneal mass and could delineate its location, outline, internal structure as well as its relationship with the surrounding organs. However, specific diagnosis for the retroperitoneal mass still relies on postoperative histopathological diagnosis. In addition, histopathological diagnosis is required to define the paraganglioma as benign or malignant tumours exhibit similar clinical diagnosis and imaging findings . Chromogranin A and synaptophysin are the most common neuropeptides synthesized in endocrine cells and can be used for immunohistochemical analysis of paragangliomas along with other protein markers such as neuron specific enolase and vimentin. They can aid the correct diagnosis of this rare disease. Our immunohistochemical analysis revealed that the tumor was positive for Chromogranin A, vimentin, S-100, synaptophysin, thus providing a histopathological basis for a correct diagnosis of nonchromaffin paraganglioma of the retroperitoneum in the patient. Zhao et al. described a case of pigmented paraganglioma showing weak expression of chromogranin A, but the tumor cells were negative for vimentin and devoid of the S-100 protein positive cells . Okubo et al. report a case of duodenal gangliocytic paraganglioma tumor cells showing positive response for synaptophysin . In these studies [7, 8], the Ki-67 labeling index was less than 1%, which is similar to our results.
Most paragangliomas are benign in nature and the malignancy rate is about 10%to 15% . The presence of metastatic lesions is considered to be the only acceptable fact for malignant paraganglioma and is used to discriminate between malignant and benign paraganglioma. The combination of a large size, heterogeneous density, and irregular margins has been suggested to have an increased likelihood of malignancy . In addition, an extra-adrenal tumor location and high tumor weight (more than 80 grams) were also considered to have an increased chance of malignant paraganglioma . Metastasis of paraganglioma of the retroperitoneum is usually to lungs, lymph nodes, liver, bones, or the spleen., The presence of paraganglia tissue in these organs strongly indicates a metastasis. We are aware of one reported case regarding paraganglioma of the retroperitoneum with direct invasion of the spinal canal which lead a cross section syndrome of the cauda equine . It has been no previous report of metastasis to the lumbar vertebra on paraganglioma of the retroperitoneum. Our case suggests that metastatic paraganglioma of the retroperitoneum should be considered as a rare case of metastases in the differential diagnosis of vertebral masses.
Management paragangliomas of the retroperitoneum with metastases remains a very challenging task as complete surgical removal of the tumor as well as the metastasis offer the only chance for cure and no other therapeutic methods have been shown to provide long-term survival. Meticulous and complete surgical removal of the original tumor and its metastasis has been reported to associate with long-term survival . Most paragangliomas have an intact capsule with abundant blood vessels both on its surface and inside. Therefore, most paragangliomas can be removed without much difficulty if the tumor is meticulously resected. A thoraco-abdominal incision is indicated if an adrenal tumor is large , which provides an adequate exposure of the tumor mass in the peritoneal cavity and greater maneuverability for operation. The patient does not have any sign of tumor recurrence after four years of surgery, suggesting the surgery is successful and effective. Our results demonstrate the need to consider paraganglioma of the retroperitoneum in the differential diagnosis of retroperitoneal mass and in the differential diagnosis of metastatic tumors to the vertebra. They also illustrate the importance of radical surgery for a successful management of paraganglioma of the retroperitoneum with metastasis.
Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in Chief of this journal.
This work was supported by the Natural science foundation of Hunan Province (No.:10JJ5042). The authors thank Dr. Yi Min Zhu for all his support and encouragement. The authors thank Jiang Yong and Zhi Feng Yin for their technical support and pathological advice.
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