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  1. Case Report

    An unusual case of Epstein-Barr virus-positive large B-cell lymphoma lacking various B-cell markers

    Epstein-Barr virus (EBV) is associated with B-cell lymphoma in various conditions, such as immunodeficiency and chronic inflammation. We report an unusual case of EBV-positive diffuse large B-cell lymphoma (DL...

    Shin-ichi Nakatsuka, Chikao Yutani, Masako Kurashige, Masaharu Kohara, Teruaki Nagano, Takayoshi Goto, Hiroyuki Takatsuka, Hidetaka Ifuku and Eiichi Morii

    Diagnostic Pathology 2017 12:15

    Published on: 31 January 2017

  2. Case Report

    Anastomosing hemangioma: report of two renal cases and analysis of the literature

    Anastomosing hemangioma (AH) is a very rare vascular tumor mimicking angiosarcoma, predominately observed in kidney and less frequently in other organs. We present two new renal cases of AH at opposite ends of...

    Marina Perdiki, Galateia Datseri, George Liapis, Nikolaos Chondros, Ioannis Anastasiou, Maria Tzardi, Johanna K. Delladetsima and Elias Drakos

    Diagnostic Pathology 2017 12:14

    Published on: 24 January 2017

  3. Research

    SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

    SESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellul...

    Shaosen Chen, Weigang Yan, Weiya Lang, Jing Yu, Li Xu, Xinyu Xu, Yunlong Liu and Hongguang Bao

    Diagnostic Pathology 2017 12:13

    Published on: 24 January 2017

  4. Case Report

    Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review

    Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owin...

    Sohsuke Yamada, Mari Kirishima, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka and Akihide Tanimoto

    Diagnostic Pathology 2017 12:11

    Published on: 19 January 2017

  5. Case Report

    Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation

    Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior.

    Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga and Armando Gamboa-Dominguez

    Diagnostic Pathology 2017 12:7

    Published on: 14 January 2017

  6. Research

    A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies

    Despite new treatment options for hepatocellular carcinomas (HCC) recently, 5-year survival remains poor, ranging from 50 to 70%, which may attribute to the lack of early diagnostic biomarkers. Thus, developin...

    Feifei Wang, Ruliang Wang, Qiuwen Li, Xueling Qu, Yixin Hao, Jingwen Yang, Huixia Zhao, Qian Wang, Guanghui Li, Fengyun Zhang, He Zhang, Xuan Zhou, Xioumei Peng, Yang Bian and Wenhua Xiao

    Diagnostic Pathology 2017 12:4

    Published on: 13 January 2017

  7. Research

    Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma

    The Cks1 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor p27kip1. It has been reported that aberrant expression of Cks1 and p27kip1 proteins was found in v...

    Lina Xu, Songqing Fan, Jin Zhao, Peng Zhou, Shuzhou Chu, Jiadi Luo, Qiuyuan Wen, Lingjiao Chen, Sailan Wen, Li Wang and Lei Shi

    Diagnostic Pathology 2017 12:2

    Published on: 7 January 2017

  8. Research

    Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma

    Double-hit lymphomas (DHL) are rare high-grade neoplasms characterized by two translocations: one involving the gene MYC and another involving genes BCL2 or BCL6, whose diagnosis depends on cytogenetic examinatio...

    Cristiano Claudino Oliveira, Helena Maciel-Guerra, Luan Kucko, Eric Jun Hirama, Américo Delgado Brilhante, Francisco Carlos Quevedo, Isabela Werneck da Cunha, Fernando Augusto Soares, Ligia Niero-Melo, Patrícia Pintor dos Reis and Maria Aparecida Custodio Domingues

    Diagnostic Pathology 2017 12:3

    Published on: 7 January 2017

  9. Case Report

    Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus

    Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we des...

    Daphne Yau, Elisa De Franco, Sarah E. Flanagan, Sian Ellard, Miriam Blumenkrantz and John J. Mitchell

    Diagnostic Pathology 2017 12:1

    Published on: 3 January 2017

  10. Case Report

    Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report

    Diffuse large B-cell lymphoma (DLBCL) typically leads to effacement of the nodal architecture by an infiltrate of malignant cells. Rarely (<1%), DLBCL can present with an interfollicular pattern (DLBCL-IF) pre...

    Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik and Agata M. Bogusz

    Diagnostic Pathology 2016 11:137

    Published on: 19 December 2016

  11. Research

    Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases

    The origin and heterogeneity of hepatic progenitor cells (HPCs) remain unclear. This study aimed to investigate the involvement of epithelial-mesenchymal transition (EMT) in the histogenesis of HPCs.

    Wei Xu, Nong-Rong Wang, Hua-Feng Wang, Qiong Feng, Jun Deng, Zhi-Qiang Gong, Jian Sun, Xiao-Liang Lou, Xue-Feng Yu, Lv Zhou, Jin-Ping Hu, Xiao-Feng Huang, Xiao-Qing Qi, Yan-Juan Deng, Rui Gong, Yan Guo…

    Diagnostic Pathology 2016 11:136

    Published on: 24 November 2016

  12. Research

    Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis

    Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has high short-term mortality with unknown causes. To predict this malignant condition in clinics is challenging. In this study, we aim to demonstra...

    Haiyan Min, Shanshan Fan, Shiyu Song, Yi Zhuang, Hui Li, Yongzheng Wu, Hourong Cai, Long Yi, Jinghong Dai and Qian Gao

    Diagnostic Pathology 2016 11:135

    Published on: 23 November 2016

  13. Case Report

    Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

    Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT ...

    Cristina Munteanu, Daniel Pirici, Alex Emilian Stepan, Adrian Camen and Claudiu Margaritescu

    Diagnostic Pathology 2016 11:134

    Published on: 21 November 2016

  14. Case Report

    Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report

    Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these pa...

    Anna-Lena Volckmar, Volker Endris, Farastuk Bozorgmehr, Clemens Lier, Carlota Porcel, Martina Kirchner, Jonas Leichsenring, Roland Penzel, Michael Thomas, Peter Schirmacher, Arne Warth and Albrecht Stenzinger

    Diagnostic Pathology 2016 11:133

    Published on: 18 November 2016

  15. Case Report

    Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report

    Inflammatory myofibroblastic tumor (IMT) is a rare low-grade malignant neoplasm with a predilection for children and young adults, and typically arises in the lung, abdominopelvic region, and retroperitoneum. ...

    Yoko Tateishi, Koji Okudela, Shigeo Kawai, Takehisa Suzuki, Shigeaki Umeda, Mai Matsumura, Mitomu Kioi and Kenichi Ohashi

    Diagnostic Pathology 2016 11:132

    Published on: 15 November 2016

  16. Research

    Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study

    Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance ...

    Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei and Zenya Naito

    Diagnostic Pathology 2016 11:131

    Published on: 15 November 2016

  17. Case Report

    Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions

    Uterine serous endometrial intraepithelial carcinoma (SEIC) is an immediate precursor of invasive carcinoma. The majority of stage IA SEICs are curable, but those with latent peritoneal metastasis and/or capil...

    Mitsuko Furuya, Teiko Sato, Reiko Tanaka, Masafumi Yamamoto, Naho Ruiz Yokota and Etsuko Miyagi

    Diagnostic Pathology 2016 11:130

    Published on: 14 November 2016

  18. Research

    The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure

    As the World Health Organization grading system for gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) may not always correlate with tumor progression, it is imperative that other independent predictors o...

    Yoichiro Okubo, Osamu Motohashi, Norisuke Nakayama, Ken Nishimura, Rika Kasajima, Yohei Miyagi, Manabu Shiozawa, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Madoka Nito, Yoichi Kameda and Tomoyuki Yokose

    Diagnostic Pathology 2016 11:128

    Published on: 8 November 2016

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