From: Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts
Antibody | Number of cases tested | Number positive | Percentage positive | Morphologic component positive | Reference(s) |
---|---|---|---|---|---|
EMA | 14 | 14 | 100 | Peri-luminary cells | 9,20 |
CD10 | 1 | 1 | 100 | All | 1 |
ER** | 2 | 1 | 50 | All | 1,11 |
PR** | 2 | 1 | 50 | All | 1,11 |
p16 | 11 | 11 | 100 | All | 1,3 |
Bcl-2 | 2 | 2 | 100 | Basaloid cells and peri-luminary cells | 1,6 |
CEA | 17 | 12 | 71 | Peri-luminary cells and squamous areas | 1,9,11,14,20 |
CAM5.2* | 9 | 8 | 89 | All | 9 |
Ki-67 | 7 | 7 | 100 | 2% positive index [6]; Majority of tumor cells positive [11]; 5–50% of basaloid cells positive [8] | 6,8,11 |
MNF116 | 9 | 9 | 100 | All | 9 |
CK7 | 13 | 7 | 54 | Basaloid cells and peri-luminary cells | 2,6,9,11 |
CK8 | 4 | 4 | 100 | Basaloid cells and peri-luminary cells | 2,6,11 |
CK10 | 1 | 1 | 100 | Squamous cells | 11 |
CK13 | 1 | 1 | 100 | Squamous cells | 11 |
CK14 | 2 | 2 | 100 | Basaloid cells [11] and other "scattered cells" [6] | 6,11 |
CK17 | 1 | 1 | 100 | Basaloid cells | 11 |
CK18 | 1 | 1 | 100 | Basaloid cells and periluminary cells | 11 |
CK19 | 1 | 1 | 100 | Basaloid cells and peri-luminary cells | 11 |
CK20 | 9 | 1 | 11 | NS | 9 |
AE1/AE3 | 6 | 6 | 100 | All | 6,20 |
CK902 | 5 | 5 | 100 | All | 20 |
α-SMA | 2 | 0 | 0 | NA | 6,11 |
MSA | 9 | 1 | 0 | Transitional areas between a combined ABC and ACC | 9 |
Laminin | 10 | 1 | 10 | Basement membrane-like material | 6,9 |
Type IV collagen | 10 | 1 | 10 | Basement membrane-like material | 6,9 |
S100 | 16 | 3 | 19 | NS | 6,9,11,20 |
CA125 | 1 | 0 | 0 | NA | 11 |
P53 | 6 | 6 | 100 | NS | 11,13 |
P63 | 6 | 6 | 100 | All: reduction of staining in squamous areas and "adenoid" areas | 1,8 |