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Table 2 Immunophenotype of Adenoid Basal Lesions.

From: Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts

Antibody Number of cases tested Number positive Percentage positive Morphologic component positive Reference(s)
EMA 14 14 100 Peri-luminary cells 9,20
CD10 1 1 100 All 1
ER** 2 1 50 All 1,11
PR** 2 1 50 All 1,11
p16 11 11 100 All 1,3
Bcl-2 2 2 100 Basaloid cells and peri-luminary cells 1,6
CEA 17 12 71 Peri-luminary cells and squamous areas 1,9,11,14,20
CAM5.2* 9 8 89 All 9
Ki-67 7 7 100 2% positive index [6]; Majority of tumor cells positive [11]; 5–50% of basaloid cells positive [8] 6,8,11
MNF116 9 9 100 All 9
CK7 13 7 54 Basaloid cells and peri-luminary cells 2,6,9,11
CK8 4 4 100 Basaloid cells and peri-luminary cells 2,6,11
CK10 1 1 100 Squamous cells 11
CK13 1 1 100 Squamous cells 11
CK14 2 2 100 Basaloid cells [11] and other "scattered cells" [6] 6,11
CK17 1 1 100 Basaloid cells 11
CK18 1 1 100 Basaloid cells and periluminary cells 11
CK19 1 1 100 Basaloid cells and peri-luminary cells 11
CK20 9 1 11 NS 9
AE1/AE3 6 6 100 All 6,20
CK902 5 5 100 All 20
α-SMA 2 0 0 NA 6,11
MSA 9 1 0 Transitional areas between a combined ABC and ACC 9
Laminin 10 1 10 Basement membrane-like material 6,9
Type IV collagen 10 1 10 Basement membrane-like material 6,9
S100 16 3 19 NS 6,9,11,20
CA125 1 0 0 NA 11
P53 6 6 100 NS 11,13
P63 6 6 100 All: reduction of staining in squamous areas and "adenoid" areas 1,8
  1. ABC: adenoid basal carcinoma; ACC adenoid cystic carcinoma; ER: estrogen receptor; PR progesterone receptor; CEA carcinoembryonic antigen; CK cytokeratin; EMA epithelial membrane antigen; NA not applicable; SMA smooth muscle actin; MSA muscle specific actin; NS not stated.** stromal cells only were positive for ER and PR in one case [11].
  2. *Cases reported by Brainard and Hart [10] are excluded because it is not clearly stated how many cases were tested.