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Table 1 Comparison Between Immunophenotypes and Ultrastructural Features of Neoplastic Cells in Present Case and Lymphoid Tissue Phagocytic and Accessory Cells Neoplasms*

From: Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component

IM/US** Case HS LCS IDCS FDCS
Lysozyme ++ ++ + + +
CD163 ++ N/A N/A N/A N/A
CD68 ++ ++ + + +
S-100 + + ++ ++ +
CD1a - - ++ - -
CD21 - - - - ++
CD23 - - - - ++
EMA - - - - +
Fascin N/A - - - +
Clusterin N/A - - - ++
CD45 + + + + ++
CD3 - - - - -
CD4 + + + - -
CD20 - - - - -
MHC II N/A + ++ + -
Lysosomes Numerous Numerous Variable Scattered Scattered
Birbeck granules - - ++ - -
Desmosomes - - - - ++
IDCP*** - - - ++ -
  1. * References: 1, 5, 6, 10–12
  2. ** IM/US: Immunohistochemical marker/ultrastructure
  3. ***IDCP: Interdigitating cell processes
  4. +: weak
  5. ++: strong
  6. HS: Histiocytic sarcoma
  7. LCS: Langerhans cell sarcoma
  8. IDCS: Interdigitating dendritic cell sarcoma
  9. FDCS: Follicular dendritic cell sarcoma