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Table 2 Expression of EBV and Topo II in the normal oral tissues, oral epithelial dysplasia and oral squamous cell carcinomas

From: The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC)

HISTOLOGY Number of cases EBV expression(%)(a) P-value Topo II- LI (%)(b) P-value
NSE 20 0.000 ± 0.000 d 5.35 ± 2.22 c
OED 16 25.6 ± 25.38   14.08 ± 2.99  
Mild 7 13.43 ± 13.24 NS 12.27 ± 2.17 NS
Moderate 5 24.00 ± 22.62   13.50 ± 1.86  
Severe 4 48.75 ±   17.98 ± 1.51  
OSCC 22 41.79 ± 29.31   27.56 ± 7.49  
W-scc 10 36.09 ± 22.37   22.40 ± 3.19  
M-scc 8 41.15 ± 33.18 NS 28.54 ± 4.84 e
P-scc 4 57.33 ± 38.91   39.00 ± 6.45  
  1. NSE, normal squamous epithelium; OED, OraLepithelial dysplasia; OSCC, oral squamous cell carcinoma; NS, not significant.
  2. a mean ± standered deviation of EBV
  3. b mean ± standered deviation of Topo II-α LI.
  4. c NSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P = 0.083.
  5. dNSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P < 0.001.
  6. eW-SCC vs. M-SCC, P = 0.008; W-SCC 1 vs.P-SCC, P = 0.001; W-SCC vs. M-SCC +P-SCC, P < 0.001.