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Table 1 Sensitivity and specificity of ANA and its clinically important subtypes [18, 19]

From: Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

Autoantibodies Associated CTD Sensitivity Specificity
ANA SLE 93 57
  Sjogren's syndrome 48 52
  SS 85 54
  PM/dermatomyositis 61 63
  Raynaud phenomena 64 41
Specific ANA    
Anti-dsDNA SLE 57 97
Anti-Sm SLE 25–30 High*
Anti-SSA/Ro Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome 8–70 87
Anti-SSB/La Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome 16–40 94
Anti-U3-RNP SS 12 96
Anticentromere Limited cutaneous SS 65 99.9
Scl-70 SS 20 100
Jo-1 PM 30 95
  1. * Precise data not available.