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Table 1 Sensitivity and specificity of ANA and its clinically important subtypes [18, 19]

From: Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

Autoantibodies

Associated CTD

Sensitivity

Specificity

ANA

SLE

93

57

 

Sjogren's syndrome

48

52

 

SS

85

54

 

PM/dermatomyositis

61

63

 

Raynaud phenomena

64

41

Specific ANA

   

Anti-dsDNA

SLE

57

97

Anti-Sm

SLE

25–30

High*

Anti-SSA/Ro

Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome

8–70

87

Anti-SSB/La

Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome

16–40

94

Anti-U3-RNP

SS

12

96

Anticentromere

Limited cutaneous SS

65

99.9

Scl-70

SS

20

100

Jo-1

PM

30

95

  1. * Precise data not available.