TY - JOUR AU - Schaaf, Bernhard AU - Luitjens, Karen AU - Goldmann, Torsten AU - van Bremen, Tobias AU - Sayk, Friedhelm AU - Dodt, Christoph AU - Dalhoff, Klaus AU - Droemann, Daniel PY - 2009 DA - 2009/04/16 TI - Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes JO - Diagnostic Pathology SP - 12 VL - 4 IS - 1 AB - Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2 and TLR4. SN - 1746-1596 UR - https://doi.org/10.1186/1746-1596-4-12 DO - 10.1186/1746-1596-4-12 ID - Schaaf2009 ER -