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Table 1 Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the simple protocol.

From: p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

   p16INK4A immunostaining
  n Negative* Positive#
Normal cervix 10 10 (100.0) 0 (0)
CIN1 249 69 (27.7) 180 (72.3)
CIN2 233 21 (9.0) 212 (91.0)
CIN3 181 3 (1.7) 178 (98.3)
ICC 133 2 (1.5) 131 (98.5)
  1. *Negative: no staining or weak staining in less than 10% of epithelial cells.
  2. #Positive: moderate or strong staining in more than 10% of epithelial cells.
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Diagnostic Pathology

ISSN: 1746-1596

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