Table 2 Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the immunohistological score.
n | p16INK4A immunostaining* | ||||||||
|---|---|---|---|---|---|---|---|---|---|
0 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
Normal | 10 | 7 (70.0) | 3 (30.0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
CIN1 | 249 | 47 (18.9) | 22 (8.8) | 18 (7.2) | 35 (14.1) | 19 (7.6) | 20 (8.0) | 12 (4.8) | 76 (30.5) |
CIN2 | 233 | 10 (4,3) | 11 (4.7) | 14 (6.0) | 15 (6.4) | 13 (5.6) | 18 (7.7) | 7 (3.0) | 145 (62.2) |
CIN3 | 181 | 3 (1.7) | 0 (0) | 3 (1.7) | 3 (1.7) | 2 (1.1) | 3 (1.7) | 5 (2.8) | 162 (89.5) |
ICC | 133 | 2 (1.5) | 0 (0) | 2 (1.5) | 1 (0.8) | 1 (0.8) | 1 (0.8) | 3 (2.3) | 123 (92.5) |