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Table 2 Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the immunohistological score.

From: p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

  n p16INK4A immunostaining*
   0 2 3 4 5 6 7 8
Normal 10 7
(70.0)
3
(30.0)
0
(0)
0
(0)
0
(0)
0
(0)
0
(0)
0
(0)
CIN1 249 47
(18.9)
22
(8.8)
18
(7.2)
35
(14.1)
19
(7.6)
20
(8.0)
12
(4.8)
76
(30.5)
CIN2 233 10
(4,3)
11
(4.7)
14
(6.0)
15
(6.4)
13
(5.6)
18
(7.7)
7
(3.0)
145
(62.2)
CIN3 181 3
(1.7)
0
(0)
3
(1.7)
3
(1.7)
2
(1.1)
3
(1.7)
5
(2.8)
162
(89.5)
ICC 133 2
(1.5)
0
(0)
2
(1.5)
1
(0.8)
1
(0.8)
1
(0.8)
3
(2.3)
123
(92.5)
  1. * Samples were assigned an immunohistological score (0 – 8) according to the intensity of staining and the proportion of stained cells in the cervical epithelium. The total score was the sum of score for stain intensity (0 – 3 points: 0 – no staining; 1 – weak staining; 2 points – moderate staining; and 3 – strong staining) and the score for propoertion of epithelial cells stained (0 – 5 points: 0 – no staining; 1 – <1% nuclei positive; 2 – 1% – 10% nuclei positive; 3 – 11% – 33% nuclei positive; 4 – 34% – 66% nuclei positive; and 5 – > 66% of nuclei positive).