Table 1 FISH results according to UCCC criteria and 7q31 control

1

1.13

5.35 (3-8)

4.7 (2-8)

85%

P

2.02 (1-4)

4 (2-8)

P

2

1.50

8.4 (4-17)

5.55 (2-10)

100%

10% of cells with >15 EGFR copies

A

8.58 (4-14)

7.2 (2-13)

P

3

1.09

4.48 (3-9)

4.1 (2-9)

89%

P

3.97 (2-5)

4.8 (2-7)

P

4

2.80

12.42 (5-23)

4 (2-7)

100%

EGFR/CEP7 Ratio >2

A

2(2)

5.3 (4-8)

A

5

1.50

7.4 (3-16)

4.9 (2-8)

100%

22,5% of cells with tight gene clusters

A

4.48 (2-9)

4 (2-7)

A

6

1.45

6.2 (3-12)

4.2 (2-8)

84%

P

4.44 (3-7)

4.72 (2-7)

P

7

1.0

15.2 (10-40)

14.5 (8-35)

100%

80% of cells with >15 EGFR copies

A

1.70

18 (12-45)

A

8

1.16

5.58 (3-10)

4.78 (3-9)

97%

P

2.37 (1-4)

5.2 (4-10)

P

9

1.05

4.92 (2-11)

4.64 (2-9)

82%

P

5.07 (2-9)

6.7 (2-11)

P

10

1.69

8.52 (4-22)

5.04 (2-9)

97%

2.4% of cells with >15 EGFR copies

P

2.2 (1-4)

5 (2-12)

A

11

1.24

4.89 (2-10)

3.93 (2-8)

75%

P

6.07 (3-12)

6 (2-10)

P

12

1.32

7.96 (3-15)

6.01 (3-9)

97%

2,7% of cells with >15 EGFR copies

P

3.2 (1-6)

6 (3-10)

P

13

1.25

10.5 (4-26)

8.36 (4-23)

100%

16% of cells with >15 EGFR copies

A

2.6 (2-5)

7.7 (4-18)

A

14

1.06

5.95 (2-13)

5.6 (2-12)

100%

P

4.1 (2-5)

6.3 (2-11)

P

15

1.18

4.39 (2-13)

3.72 (1-13)

72%

P

3.36(2-5)

3.9 (2-10)

P

16

1.22

4.64 (2-9)

3.78 (2-6)

71%

P

2.35 (1-3)

4.2 (2-7)

P

17

1.70

3.9 (1-8)

2.2 (1-5)

55%

P

2.24 (1-4)

3 (2-6)

P

18

1.10

4.9 (2-8)

4.4 (2-7)

90%

P

6.02 (4-9)

7.4 (2-10)

P

19

1.40

6.4 (3-23)

4.7 (1-10)

93%

Tight gene clusters in 11,5% of cells

A

4.15 (2-7)

5.6 (2-10)

A

20

2.90

8.8 (2-13)

3.1 (2-6)

88%

EGFR/CEP7 Ratio >2

A

1.6 (1-3)

2.1 (2-5)

A