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Table 1 FISH results according to UCCC criteria and 7q31 control

From: Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer

Case
EGFR/CEP7 Ratio EGFR/NUCLEI Ratio (Range) CEP7/NUCLEI Ratio(Range) % of cells with >4 EGFR copies NOTES RESULTS (UCCC criteria) 7q31/NUCLEI Ratio (Range) CEP7/NUCLEI Ratio (Range) RESULTS (7q31 control)
1 1.13 5.35 (3-8) 4.7 (2-8) 85%   P 2.02 (1-4) 4 (2-8) P
2 1.50 8.4 (4-17) 5.55 (2-10) 100% 10% of cells with >15 EGFR copies A 8.58 (4-14) 7.2 (2-13) P
3 1.09 4.48 (3-9) 4.1 (2-9) 89%   P 3.97 (2-5) 4.8 (2-7) P
4 2.80 12.42 (5-23) 4 (2-7) 100% EGFR/CEP7 Ratio >2 A 2(2) 5.3 (4-8) A
5 1.50 7.4 (3-16) 4.9 (2-8) 100% 22,5% of cells with tight gene clusters A 4.48 (2-9) 4 (2-7) A
6 1.45 6.2 (3-12) 4.2 (2-8) 84%   P 4.44 (3-7) 4.72 (2-7) P
7 1.0 15.2 (10-40) 14.5 (8-35) 100% 80% of cells with >15 EGFR copies A 1.70 18 (12-45) A
8 1.16 5.58 (3-10) 4.78 (3-9) 97%   P 2.37 (1-4) 5.2 (4-10) P
9 1.05 4.92 (2-11) 4.64 (2-9) 82%   P 5.07 (2-9) 6.7 (2-11) P
10 1.69 8.52 (4-22) 5.04 (2-9) 97% 2.4% of cells with >15 EGFR copies P 2.2 (1-4) 5 (2-12) A
11 1.24 4.89 (2-10) 3.93 (2-8) 75%   P 6.07 (3-12) 6 (2-10) P
12 1.32 7.96 (3-15) 6.01 (3-9) 97% 2,7% of cells with >15 EGFR copies P 3.2 (1-6) 6 (3-10) P
13 1.25 10.5 (4-26) 8.36 (4-23) 100% 16% of cells with >15 EGFR copies A 2.6 (2-5) 7.7 (4-18) A
14 1.06 5.95 (2-13) 5.6 (2-12) 100%   P 4.1 (2-5) 6.3 (2-11) P
15 1.18 4.39 (2-13) 3.72 (1-13) 72%   P 3.36(2-5) 3.9 (2-10) P
16 1.22 4.64 (2-9) 3.78 (2-6) 71%   P 2.35 (1-3) 4.2 (2-7) P
17 1.70 3.9 (1-8) 2.2 (1-5) 55%   P 2.24 (1-4) 3 (2-6) P
18 1.10 4.9 (2-8) 4.4 (2-7) 90%   P 6.02 (4-9) 7.4 (2-10) P
19 1.40 6.4 (3-23) 4.7 (1-10) 93% Tight gene clusters in 11,5% of cells A 4.15 (2-7) 5.6 (2-10) A
20 2.90 8.8 (2-13) 3.1 (2-6) 88% EGFR/CEP7 Ratio >2 A 1.6 (1-3) 2.1 (2-5) A
  1. A = Amplification; P = Polysomy