Table 1 Chronic changes noted in renal allograft biopsies of 2 groups, Ahmedabad Tolerance Induction Protocol (ATIP) vs. controls:

(n = 1151)

(n = 974)

(n = 177)

Chronic changes (n = 135)

107 (10.98%)

31 (17.5%)

Mean follow-up (months) (range)

130.9 (23–277)

151.9 (13.9–280)

Male: female

87:20:00

21:10

Hypertension (BP > 130/90 mm Hg)

71 (66.4%)

13 (41.9%)

Proteinuria (24 hrs urine albumin > 800 mg)

46 (43%)

25(80.6%)

HISTOPATHOLOGY

Interstitial fibrosis+ tubular atrophy

107 (100%)

31 (100%)

Focal global sclerosis

50 (46.7%)

21 (67.7%)

Chronic transplant glomerulopathy

35 (32.7%)

15 (48.4%)

C4d deposits

2(1.9%)

6 (19.4%)

Acute on chronic calcineurin inhibitor toxicity

77 (71.9%)

15 (48.4%)

Acute on chronic T/B cell rejection

30 (28.1%)

16 (51.6%)