Table 3 Immunohistochemical and FISH data
From: Overexpression of c-erb B2 is a negative prognostic factor in anaplastic astrocytomas
Case no. | c-erb B-1 (clone EGFR.25) (internal domain) | c-erb B-1 (clone EGFR.113) (external domain) | c-erb B-2 (clone CB11) (internal domain) | c-erb B-2 (clone 3B5) (internal domain) | c-erb B-2 (clone 5A2) (internal domain) | c-erb B-3 | c-erb B-4 | EGFR gene amplification (FISH) |
|---|---|---|---|---|---|---|---|---|
1 | 9 | 9 | 4 | 6 | 6 | 9 | 4 | Yes |
2 | 9 | 1 | 0 | 9 | 3 | 4 | 2 | No |
3 | 6 | 0 | 4 | 3 | 1 | 9 | 0 | No |
4 | 6 | 1 | 1 | 9 | 0 | 0 | 0 | No |
5 | 0 | 0 | 4 | 6 | 2 | 6 | 4 | No |
6 | 1 | 9 | 1 | 4 | 0 | 4 | 0 | Yes |
7 | 9 | 9 | 0 | 1 | 0 | 0 | 0 | No |
8 | 6 | 2 | 0 | 6 | 4 | 6 | 4 | Yes |
9 | 9 | 9 | 2 | 6 | 0 | 6 | 6 | No |
10 | 9 | 9 | 0 | 9 | 1 | 9 | 4 | Yes |
11 | 4 | 0 | 2 | 6 | 0 | 4 | 4 | Yes |
12 | 9 | 4 | 0 | 6 | 2 | 9 | 2 | Yes |
13 | 9 | 2 | 4 | 6 | 1 | 9 | 2 | No |
14 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | No |
15 | 2 | 1 | 0 | 9 | 1 | 6 | 0 | No |
16 | 6 | 0 | 0 | 4 | 0 | 6 | 1 | No |
17 | 9 | 2 | 0 | 9 | 4 | 9 | 2 | No |
18 | 4 | 1 | 6 | 9 | 1 | 4 | 4 | No |
19 | 4 | 0 | 0 | 1 | 0 | 4 | 0 | Yes |
20 | 6 | 1 | 1 | 6 | 0 | 6 | 1 | Yes |
21 | 6 | 4 | 1 | 6 | 0 | 4 | 2 | No |
22 | 9 | 6 | 2 | 6 | 6 | 4 | 2 | No |
23 | 9 | 3 | 0 | 6 | 0 | 1 | 0 | No |
24 | 6 | 0 | 0 | 6 | 3 | 6 | 2 | No |
25 | 6 | 2 | 1 | 6 | 3 | 9 | 2 | No |
26 | 6 | 4 | 6 | 6 | 2 | 4 | 1 | Yes |
27 | 6 | 0 | 0 | 1 | 0 | 2 | 1 | No |
28 | 6 | 1 | 0 | 4 | 0 | 4 | 1 | No |
29 | 9 | 6 | 0 | 4 | 0 | 0 | 1 | No |
30 | 3 | 0 | 0 | 4 | 0 | 2 | 2 | No |
31 | 6 | 1 | 0 | 9 | 3 | 9 | 6 | No |
Median Staining Index | 6 | 1 | 0 | 6 | 1 | 4 | 2 | Â |
No. of positive cases/Total no. of cases | 30/31 | 22/31 | 14/31 | 31/31 | 16/31 | 27/31 | 23/31 | 9/31 |
Percentage positivity | 97% | 71% | 45% | 100% | 52% | 97% | 74% | 29% |