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Table 4 Results from multiple Cox regression analyses

From: Overexpression of c-erb B2 is a negative prognostic factor in anaplastic astrocytomas

Variable Hazard ratio 95% Confidence interval P
c-erbB1 (clone EGFR.113) staining index 1.076 0.92 to 1.26 0.37
Karnofsky performance status 0.913 0.85 to 0.98 0.008
Gross total resection 0.196 0.05 to 0.79 0.022
Age 0.998 0.95 to 1.05 0.95
c-erbB1 (clone EGFR.25) staining index 0.991 0.80 to 1.23 0.93
Karnofsky performance status 0.912 0.85 to 0.98 0.009
Gross total resection 0.199 0.05 to 0.82 0.026
Age 1.007 0.96 to 1.06 0.79
c-erbB2 (clone CB11) staining index 1.642 1.17 to 2.30 0.004
Karnofsky performance status 0.854 0.78 to 0.94 0.001
Gross total resection 0.324 0.08 to 1.38 0.13
Age 0.973 0.92 to 1.03 0.36
c-erbB2 (clone 5A2) staining index 1.036 0.79 to 1.35 0.80
Karnofsky performance status 0.910 0.85 to 0.98 0.009
Gross total resection 0.186 0.05 to 0.78 0.021
Age 1.005 0.96 to 1.06 0.85
c-erbB2 (clone 3B5) staining index 1.018 0.84 to 1.23 0.86
Karnofsky performance status 0.912 0.85 to 0.98 0.009
Gross total resection 0.190 0.05 to 0.77 0.020
Age 1.006 0.96 to 1.06 0.81
c-erbB3 (clone RTJ1) staining index 0.975 0.83 to 1.15 0.76
Karnofsky performance status 0.914 0.85 to 0.98 0.010
Gross total resection 0.204 0.05 to 0.81 0.024
Age 1.008 0.96 to 1.06 0.74
c-erbB4 (clone HFR-1) staining index 0.902 0.68 to 1.20 0.48
Karnofsky performance status 0.907 0.85 to 0.97 0.005
Gross total resection 0.178 0.05 to 0.72 0.015
Age 1.003 0.96 to 1.05 0.90
EGFR gene amplification 0.689 0.23 to 2.11 0.51
Karnofsky performance status 0.919 0.86 to 0.99 0.021
Gross total resection 0.175 0.04 to 0.73 0.017
Age 1.013 0.96 to 1.07 0.63
  1. Multiple Cox regression analyses were used to study the association between c-erb B1-4 expression and survival, adjusting for age at diagnosis, Karnofsky performance status scores, and extent of surgical resection. The association between EGFR amplification and survival was studied in the same manner.