Intrauterine growth restriction and placental angiogenesis

Diagnostic Pathology

Table 4 b-FGF expression in placental villous tissues

	Normal pregnancy (n: 55)				IUGR (n: 55)				Statistical comparison P value
Score	0 n (%)	1+ n (%)	2+ n (%)	3+ n (%)	0 n (%)	1+ n (%)	2+ n (%)	3+ n (%)	P*
CVSC	-	55 (100)	-	-	-	-	-	55 (100)	<0.001
VSMC	43 (78.2)	12 (21.8)	-	-	-	-	-	55 (100)	<0.001
VVEC	43 (78.2)	12 (21.8)	-	-	-	-	-	55 (100)	<0.001
ST	-	55 (100)	-	-	-	-	-	55 (100)	<0.001
CT	-	55 (100)	-	-	-	-	-	55 (100)	<0.001
EVT	55 (100)	-	-	-	-	-	-	55 (100)	<0.001

IUGR: Intrauterine growth restricted; CVSC: Chorionic villous stromal cells; VSMC: Vascular smooth muscle cells; VVEC: Villous vascular endothelial cells; ST: Syncytiotrophoblasts; CT; Cytotrophoblasts; EVT: Extravillous trophoblasts [Staining intensity of FGF-b were scored as follows: 0 (negative), weak (1+), moderate (2+), and strong (3+)] *P: Statistical comparison of normal and IUGR placental tissues