Table 4 Possible causes of diagnostic discordance related to time of diagnosis
From: Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry
Possible causes | Pat. ID | Sex | Year | Our tentative HES diagnosis | Primarily registered MM diagnoses changed to: |
|---|---|---|---|---|---|
Right histological diagnosis (without use of IHC) not accepted by clinicians, registered as MM in Cancer Registry | 5 3 6 | M M M | 1986 1988 1988 | MM/LMS MM MM/C | undetermined: sarcoma, lung or pleura/sarcomatous MM, pleura AC, lung pleomorphic carcinoma, lung |
No IHC | 9 | M | 1991 | MM/C | pleomorphic carcinoma, lung |
Use of non-specific markers | 57 72 31 49 | M M M F | 1989 1996 1998 1998 | MM MM/C Mal. tu. S/LMS? | undetermined: sarcoma, lung or pleura/sarcomatous MM, pleura AC, lung pleomorphic carcinoma, lung undetermined: sarcoma/sarcomatoid carcinoma, peritoneum |
Differences in IR1 | 58 | F | 1999 | MM/C | AC, peritoneum |
Not appropriate conclusions2 | 32 63 12 | M M M | 1999 2001 2002 | MM Ben./MM? Mal. Mel. | undetermined: sarcoma, lung or pleura/sarcomatous MM, pleura undetermined: sarcoma, lung or pleura/sarcomatous MM, pleura undetermined: AC, lung > MM, pleura |