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Table 9 Survival-related single factors, tendencies of correlation

From: Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry

Factor

Relation to survival, clear tendency

Significant (only) in bivariate correlation with survival (two-tailed), level

IHC markers, semiquantitatively, when increasing number of cells with positive IR:

  

Calretinin, nucleus

-

Calretinin, cytoplasm

-

EMA, cell membrane

-

EMA, cytoplasm

-

Podoplanin, cell membrane

0.001

Mesothelin, cell membrane

if 0-50%: ↓

51-100%: ↑

-

Ber-Ep4, general

if 1-25%: (↓)

-

Histological type

  

Epithelial

0.05 (non-parametric)

Mixed

0.01 (non-parametric)

Histological markers

  

a) when increasing:

  

Degree of cellular atypia

0.001

Spindle cells, semiquantitatively

if 0: ↑; otherwise: ↓

0.001 (non-parametric)

Number of mitoses (10 HPF)

if 0 or 1: ↑; otherwise:↓

0.05 (Spearman's rho)

Number of atypical mitoses (10 HPF)

if 0: ↑; otherwise: ↓

-

Necrosis

0.01

Mucus, cytoplasm, number of cells

if high: (↓)

-

Mucus, extracellular, number of cells

-

Accompanying inflammation, intensity

-

Accompanying inflammation, focality

-

b) if present:

  

MM spreading, perineural

(↔)

-

MM spreading, intralymphangic

(↔)

-

MM spreading, intralymphangic and venoles

(↓)

-

No/no evident MM spreading

-

Accompanying inflammation, active

(↔)

-

Accompanying inflammation, non-active

-

Localisation of primary tumour

  

Pleura

-

Peritoneum

0.01 (parametric)

0.05 (non-parametric)

Pleura and peritoneum

(↓)

-

Mediastinum, not specified

(↓)

-

Pericardium

(↓)

-

Scrotum

(↓)

-

Metastasis

 

0.05 (non-parametric)

yes

 

no/not known

 

Sex

 

-

Female

-

Male

-

Age at time of diagnosis, when increasing:

0.01

  1. In parentheses: very few cases
  2. Survival is given per April 21, 2008.