Skip to main content

Table 3 Results of immunohistochemical markers response in neurons

From: The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events

  Acute (A) (≤8 hs) Median Expression Non-acute (NA) (≥8 hs ≤48 hs) Median Expression Controls (C) Median Expression Significance Level
GFAP - -   A vs C ns
     NA vs C ns
     A vs NA ns
TNF-α - + - A vs C ***
     NA vs C ns
     A vs NA ***
IL-1β + ++ - A vs C ***
     NA vs C ***
     A vs NA ***
IL-6 - + - A vs C ***
     NA vs C ns
     A vs NA ***
MAC387 - - - A vs C ns
     NA vs C ns
     A vs NA ns
HSP 27 - - - A vs C ns
     NA vs C ns
     A vs NA ns
HSP 70 + +++ - A vs C ***
     NA vs C **
     A vs NA ***
HSP 90 + +++ - A vs C ***
     NA vs C **
     A vs NA ***
COX2 +++ + - A vs C ***
     NA vs C ***
     A vs NA **
ORP-150 ++ + - A vs C ***
     NA vs C ***
     A vs NA **
β-APP + +++ ++ A vs C ***
     NA vs C **
     A vs NA **
TrypH - + - A vs C ***
     NA vs C ns
     A vs NA ***
GAP-43 - - - A vs C ns
     NA vs C ns
     A vs NA ns
Apoptosis (TUNEL) + ++ - A vs C ***
     NA vs C **
     A vs NA ***
  1. The reactions were graded as follows: 1. (0): not expressed, 2. (+): isolated and disseminated expression, 3. (++): expression in groups or widespread foci, 4. (+++): widespread expression.
  2. NS = p > 0.05, * = p < 0.05, ** = p < 0.01, *** = p < 0.001