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Table 1 Clinicopathological findings. Chronology

From: Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: A clinicopathologic, immunohistochemical and molecular study of one case

CLINIPATHOLOGYCAL FINDINGS - CHRONOLOGY

DATE

June 2007

July 2008

February 2009

LOCATION

Mass in the right elbow

Intratesticular tumor

Patient died with multiple metastases in the left thigh, lung and mediastinum.

No autopsy was performed

HISTOLOGY

Eosinophilic hyalinizing sclerosing matrix with small round cells

Fusocellular RMS with eosinophilic matrix and rhabdomyoblasts

 

MITOSIS

4 mit/10HPF

10mit/10HPF

 

IHC (+)

Vimentin

Vimentin

 
 

MyoD1

MyoD1

 
 

SMA

SMA

 
 

CD99

CD99

 
  

myogenin

 

MIB-1

25-30%

20%

 

RT-PCR

PAX3-FKHR and PAX7-FKHR were not found.

PAX3-FKHR and PAX7-FKHR were not found.

 

FISH

FOXO1A (-)

FOXO1A (-)

 

Chemotherapy

CTX+VCR+Doxorrubicin

Ifosfamide

 

Surgery

Tumor resection

Right Orquidectomy