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Table 1 Laboratory Presentation

From: Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature

AT PRESENTATION (Normal Range) VALUE
Serum Potassium (3.8-5.2 mEq/l) 2.1
Serum HCO3 (21-32 mEq/l) 42
Plasma Glucose (mg/dl) 339
Morning Serum Cortisol (06:15) (4.0-32 μg/dl) 111.1
ENDOCRINE WORK-UP (Normal Range)
1 mg Overnight Dexamethasone Supression Test (Normal cortisol < 1.8 μg/dl) 116.7
48 hour High Dose Dexamethasone Supression Test (Normal cortisol < 1.8 μg/dl) 109.8
24 hour Urine Free Cortisol (0 to 50 μg) 16 575
Plasma ACTH (10-46 pg/ml) 278
Plasma CRHa (0-10 pg/ml) 10
Plasma Chromogranin A (0-5.0 nmol/l) 26
Serum Carcinoembryonic antigen (0-5.0 ng/ml) 10.59
Serum Calcitonin (0-5 pg/ml) < 2.0
Serum Serotonin (0-420 ng/ml) 156
Plasma Metanephrine (0-62 pg/ml) and
Normetanephrine (0-145 pg/ml)
12
37
Serum Gastrin (13.0-115.0 pg/ml) 280
24 hr Urinary 5-HIAA (0-8.0 mg) 6.7
  1. Abbreviations: ACTH, Adrenocorticotropic Hormone; CRH, Corticotropin Releasing Hormone, 5-HIAA, 5-hydroxy-indoleacetic acid
  2. aCRH assay is a plasma based test by which Corticotropin Releasing Factor is measured by direct radioimmunoassay (Inter Science Institute, Inglewood, CA).