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Table 4 Previous Reports of Immunohistochemically Detectable PSA Expression in Benign and Malignant Breast Lesions

From: Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma

Author Number of Cases Antibody, Clone PSA Positive Comments
Carder et al. 2005 [2] 11 MBC Dako, ELY, Cambridgeshire, UK 1/11 (9%) Focal intense staining
All cases PSAP negative (Dako)
Cheng et al. 2006 [3] 14 MBC Dako, Glostrup, Denmark 0/14 All cases PSAP negative
Ilvan et al. 2004 [10] 109 FBC Dako USA, monoclonal, prediluted 11/109 (10.1%) All PSA positive cases ER+ PR+
Miller et al. 2001 [11] 75 (74 FBC, 1 MBC) Dako M0750 1:320 7/75 (9%) 5/7 showed weak, focal positivity; MBC negative
Kidwai et al. 2003 [12] 26 MBC Dako polyclonal 1:1800 6/26 (23%) 5 focally positive
1 diffuse
All PSAP negative
Narita et al. 2006 [13] 156 FBC Dako polyclonal, ready to use 61/156 (39.1%) Positive correlation with AR expression
Hall et al. 1998 [14] 72 cases Dako, Carpinteria, CA 44/72 (61%)  
Alanen et al. 1999 [15] 171 cases Dakopatts, Glostrup, Denmark, polyclonal 1:1000 54/171 (31.6%)  
Gatalica et al. 1999 [19] 18 gynecomastia, 8 MBC Rabbit polyclonal, Ventana Medical Systems, Tucson AZ 5/18 cases of gynecomastia (27.8%)
0/8 MBC
Focal strong polyclonal PSA; 4/5 cases tested with monoclonal PSA and were negative
All cases PSAP (Ventana PASE/4LT) negative
Quraishi et al. 2007 [20] 30 (8 DCIS, 19 infiltrating ductal carcinoma, 3 metastatic breast carcinoma) Polyclonal rabbit 0/30  
Gupta 1999 [21] 2 MBC Not reported 2/2 (100%) Cell blocks positive; trace PSA positivity in resection specimens
Tanaka et al. 2002 [22] 78 FBC Dako A/S Glostrup, Denmark, polyclonal 1:100 29/78 (32.7%) 6 cases strongly positive
This article 54 FBC
30 MBC
5 gynecomastia
Dako polyclonal 1:10,000 2/54 FBC
1/30 MBC
0/5 gynecomastia
All cases PSAP negative
  1. MBC - male breast carcinoma; FBC - female breast carcinoma; PSA - prostate specific antigen; PSAP - prostate specific acid phosphatase; AR - androgen receptor; ER - estrogen receptor; PR - progesterone receptor.