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Table 1 Frequency of mtDNA variants among colorectal adenomatous polyps

From: Analysis of mtDNA sequence variants in colorectal adenomatous polyps

MT GENES/
REGION
MTDNA VARIANTS % FREQUENCY ADENOMATOUS POLYPS NOTES
   Tubular Tubulovillous Villous  
MT-ATP6 A9006G - - 57 * R
MT-ATP6 G9055A 100 - 57 * NR
MT-ATP6 A9093G 100 -   R
MT-ATP6 A8860G 100 100 100 R
MT-ATP6 A9169C 75    NR
MT-ATP8 C8515G/T 100 100 100 R
MT-ATP8 G8697A    43** R
MT-tRNA 8327 del A 100 100 100 R
MT-ATP6 G8864T    17*** Ra
MT-ATP6 G8865A    17*** R
MT-ATP6 A8340G    17*** R
MT-ATP6 T8363C    17*** Rb
MT-ATP 6 G8994A   85   NR
MT-ATP6 G8696A   20 43** NR
MT-ATP6 A8701G   25   R
MT-ND5 C13938G 85    NR
MT-ND5 C13939G 85    NR
MT-ND5 G13940T 85    NR
MT-ND5 C13941A 85    Rc
MT-ND5 A13942G 85    R
MT-ND5 C13943A 85    Rd
MT-ND5 13945 delA 75    NR
MT-ND5 13946 delT 85    NR
MT-ND5 C13947G 85    NR
MT-ND5 C13949T 85    NR
MT-ND5 C13960A 70    NR
MT-ND5 A13969C 70    NR
MT-ND5 A13973T 80    NR
MT-ND5 A13974T 80    NR
MT-ND5 A13975G 80    NR
MT-ND5 A13976G 80    NR
MT-ND5 C13977G 80    NR
MT-ND5 C13978G 80    NR
MT-ND5 T13979G 80    NR
MT-ND5 A13995T 80    NR
MT-ND5 G13996T 80    NR
MT-ND5 A14002G    57 * R
MT-ND5 G14040A    57 * R
MT-ND5 C14167T 75   57 * R
MT-ND6 T14180C 70    R
MT-ND6 A14233G    43 ** R
MT-ND6 14652del A    43 ** NR
M-tRNA 14715del A 80   43 ** NR
MT-CYTB A14782T 90    NR
  1. * Germ-line mutations/polymorphisms found in all our studied villous adenomas tissues samples only, but not in tissue samples designated as polyvillous adenaomas.
  2. **Germ-lines mutations/polymorphisms found in all our studied tissue samples designated as polyvillous adenomas only, but not in villous adenomas tissues samples.
  3. *** Somatic mutations found in matched surrounding paracancerous normal tissues of polyvillous adenomas in our studied tissue samples only.
  4. R Mutations/polymorphisms are previously reported.
  5. NR Mutations/polymorphisms are unreported.
  6. Ra Mutation previously reported as G8864A; Rb Mutation previously reported as A8363T.
  7. Rc Mutation previously reported as C13941G; Rd Mutation previously reported as C13943T.