Analysis of mtDNA sequence variants in colorectal adenomatous polyps

Diagnostic Pathology

Table 1 Frequency of mtDNA variants among colorectal adenomatous polyps

MT GENES/ REGION	MTDNA VARIANTS	% FREQUENCY ADENOMATOUS POLYPS			NOTES
		Tubular	Tubulovillous	Villous
MT-ATP6	A9006G	-	-	57 *	R
MT-ATP6	G9055A	100	-	57 *	NR
MT-ATP6	A9093G	100	-		R
MT-ATP6	A8860G	100	100	100	R
MT-ATP6	A9169C	75			NR
MT-ATP8	C8515G/T	100	100	100	R
MT-ATP8	G8697A			43**	R
MT-tRNA	8327 del A	100	100	100	R
MT-ATP6	G8864T			17***	R^a
MT-ATP6	G8865A			17***	R
MT-ATP6	A8340G			17***	R
MT-ATP6	T8363C			17***	R^b
MT-ATP 6	G8994A		85		NR
MT-ATP6	G8696A		20	43**	NR
MT-ATP6	A8701G		25		R
MT-ND5	C13938G	85			NR
MT-ND5	C13939G	85			NR
MT-ND5	G13940T	85			NR
MT-ND5	C13941A	85			R^c
MT-ND5	A13942G	85			R
MT-ND5	C13943A	85			R^d
MT-ND5	13945 delA	75			NR
MT-ND5	13946 delT	85			NR
MT-ND5	C13947G	85			NR
MT-ND5	C13949T	85			NR
MT-ND5	C13960A	70			NR
MT-ND5	A13969C	70			NR
MT-ND5	A13973T	80			NR
MT-ND5	A13974T	80			NR
MT-ND5	A13975G	80			NR
MT-ND5	A13976G	80			NR
MT-ND5	C13977G	80			NR
MT-ND5	C13978G	80			NR
MT-ND5	T13979G	80			NR
MT-ND5	A13995T	80			NR
MT-ND5	G13996T	80			NR
MT-ND5	A14002G			57 *	R
MT-ND5	G14040A			57 *	R
MT-ND5	C14167T	75		57 *	R
MT-ND6	T14180C	70			R
MT-ND6	A14233G			43 **	R
MT-ND6	14652del A			43 **	NR
M-tRNA	14715del A	80		43 **	NR
MT-CYTB	A14782T	90			NR

* Germ-line mutations/polymorphisms found in all our studied villous adenomas tissues samples only, but not in tissue samples designated as polyvillous adenaomas.
**Germ-lines mutations/polymorphisms found in all our studied tissue samples designated as polyvillous adenomas only, but not in villous adenomas tissues samples.
*** Somatic mutations found in matched surrounding paracancerous normal tissues of polyvillous adenomas in our studied tissue samples only.
R Mutations/polymorphisms are previously reported.
NR Mutations/polymorphisms are unreported.
R^a Mutation previously reported as G8864A; R^b Mutation previously reported as A8363T.
R^c Mutation previously reported as C13941G; R^d Mutation previously reported as C13943T.

ISSN: 1746-1596