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Table 4 Sensitivity, Specificity, Positive (PPV) and Negative (NPV) Predictive Values of the different immunomarkers (%)

From: Diagnostic utility of snail in metaplastic breast carcinoma

Stains vs. Case

N

Overall

Agreement, %

(95% CI)

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV

NPV

EGFR

60

65.0 (52.4, 75.8)

100.0 (89.9, 100.0)

19.2 (8.5, 37.9)

61.8

100.0

OSCAR

60

88.3 (77.8, 94.2)

85.3 (69.9, 93.6)

92.3 (75.9, 97.9)

93.6

82.8

P63

60

81.7 (70.1, 89.4)

67.6 (50.8, 80.9)

100.0 (87.1, 100.0)

100.0

70.3

SNAIL

60

58.3 (45.7, 71.8)

100.0 (89.9, 100.0)

3.8 (0.7, 18.9)

57.6

100.0

WSKER

60

86.7 (75.8, 93.1)

76.5 (60.0, 87.6)

100.0 (87.1, 100.0)

100.0

76.5

OSCAR & P63 & WSKER

60

90.0 (79.9, 95.3)

88.2 (73.4, 95.3)

92.3 (75.9. 97.9)

93.8

85.7

OSCAR & WSKER

60

88.3 (77.8, 94.2)

85.3 (69.9, 93.5)

92.3 (75.9, 97.9)

93.6

82.8

OSCAR & P63

60

90.0 (79.9, 95.3)

88.2 (73.4, 95.3)

92.3 (75.9. 97.9)

93.8

85.7

P63 & WSKER

60

90.0 (79.9, 95.3)

82.4 (66.5, 91.7)

100.0 (87.1, 100.0)

100.0

81.2

  1. EGFR = epidermal growth factor receptor; WS-KER = wide spectrum keratin