Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules

Table 6 Comparison of sensitivity, specificity, PPV and NPV of combined markers expression in Benign vs. Malignant Thyroid Lesions

MARKER		Negative	Positive	Total
GAL-3 + HBME-1	Benign	134	62	196	Sensitivity	0.861
	Malignant	15	93	108	Specificity	0.684
Total		149	155	304	PPV	0.600
					NPV	0.899
GAL-3 + CK-19	Benign	138	58	196	Sensitivity	0.852
	Malignant	16	92	108	Specificity	0.704
Total		154	150	304	PPV	0.613
					NPV	0.896
HBME-1 + CK-19	Benign	130	66	196	Sensitivity	0.861
	Malignant	15	93	108	Specificity	0.663
Total		145	159	304	PPV	0.585
					NPV	0.897
GAL-3+HBME+CK-19	Benign	201	93	294	Sensitivity	0.858
	Malignant	23	139	162	Specificity	0.684
Total		224	232	456	PPV	0.599
					NPV	0.897

Gal-3, galectin-3; Ret, Ret oncoprotein; CK19, cytokeratin 19; PPV, positive predictive value; NPV, negative predictive value.

ISSN: 1746-1596