Skip to main content
Figure 1 | Diagnostic Pathology

Figure 1

From: Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification

Figure 1

EGFR protein and gene status in colorectal carcinomas. Immunohistochemical expression of EGFR protein designated as discontinuous, basolateral or continuous membrane staining of different intensity: (a) week, (b) moderate and (c) strong immunostainining. Chromosome 7 copy number was analyzed in tumor cells using fluorescence in situ hybridization (FISH) with an α-satellite DNA probe for chromosome 7 (centromere 7, red signal; EGFR gene, green signal); (d) tumor nuclei without abnormality; (e) tumor cells showed polysomy with a greater number of red and green signals than in normal cells; and (f) tumor cells with amplification (a-c, magnification ×200, d-f magnification ×100).

Back to article page