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Table 1 Tumor grade, size and stage in compare to immunohistochemicals markers (mEGFR, nEGFR, Cyclin D1) and EGFR FISH in CRC

From: Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification

  

Grade

 

pT

 

Tumor stage

 

Parameters

Total

low

high

p-value

1

2

3

4

p-value

1

2

3

4

p-value

mEGFR

   

0.042

    

0.506

    

0.769

   neg./week

49

47

2

 

2

35

12

0

 

22

4

23

0

 

   moderate

64

54

10

 

0

39

23

2

 

22

9

33

0

 

   strong

22

20

2

 

0

12

9

1

 

7

4

10

1

 

nEGFR

   

0.427

    

0.452

    

0.943

   neg./week

9

9

0

 

0

6

3

0

 

4

2

3

0

 

   moderate

49

44

5

 

2

25

20

2

 

15

11

22

1

 

   strong

77

68

9

 

0

55

21

1

 

32

4

41

0

 

Cyclin D1

   

0.363

    

0.335

    

0.588

   neg./week

8

8

0

 

0

7

1

0

 

4

1

3

0

 

   moderate

51

46

5

 

2

24

22

3

 

14

11

25

1

 

   strong

76

67

9

 

0

55

21

0

 

33

5

38

0

 

EGFR FISH

   

0.486

    

0.713

    

0.178

   ≤ 2.0 - 2.49

117

106

12

 

2

78

34

3

 

47

14

56

0

 

   2.5 - 2.93

10

9

0

 

0

5

5

0

 

2

2

5

1

 

   ≥ 2.94

8

6

2

 

0

3

5

0

 

2

1

5

0

 

Total

135

121

14

 

2

86

44

3

 

51

17

66

1

 
  1. CRC, colorectal carcinoma
  2. mEGFR, membrane EGFR
  3. nEGFR, nuclear EGFR
  4. test - Spearman rank correlation coefficient
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Diagnostic Pathology

ISSN: 1746-1596

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