Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: Morphometric and immunohistochemical analysis of six autopsy cases

Table 1 Summary of patient characteristics

Case	Age	Sex	Maximum diameter of tumor (mm)	Macroscopic subtype	Histopathological subtype	Lymph-vascular involvement	Metastasis	Pulmonary arterial pressure
1	76	Male	70	Borrmann 3	por	ly-3 v-2	Lung, diaphragm, pleura, peritoneum, liver, gallbladder, pancreas, adrenal gland, lymph nodes.	90 mmHg
2	82	Female	20	Borrmann 2	por	ly-3 v-1	Lung, liver, pancreas, lymph nodes	10 mmHg
3	67	Female	30	Superficial depressed type	por	ly-3 v-1	Lung, esophagus, thyroid, pericardium, ovary, lymph nodes	Unknown
4	67	Female	75	Borrmann 3	por	ly-3 v-1	Esophagus, duodenum, ileum, jejunum, colon, mesenterium, liver, gallbladder, pancreas, kidney, adrenal gland, aorta, lymph nodes	Unknown
5	49	Female	60	Borrmann 3	pap	ly-3 v-2	Esophagus, duodenum, liver, pancreas, kidney, adrenal gland, lymph nodes	Unknown
6	72	Male	20	Borrmann 2	por	ly-3 v-1	Pancreas, spleen, kidney, adrenal gland, colon, spinal cord, lymph nodes	Unknown

por: poorly differentiated adenocarcinoma, pap: papillary adenocarcinoma, ly/v-1: minimal lympho-vascular involvement, ly/v-2: moderate lympho-vascular involvement, ly/v-3: prominent lympho-vascular involvement
Patient age ranged from 49 to 82 years (mean ± standard deviation: 68.3 ± 11.3). The gender ratio was 4:2 (male to female). Maximum diameter of the tumor ranged from 20 to 70 mm (mean ± standard deviation: 45.8 ± 25.4). Main histology of gastric carcinoma involved poorly differentiated adenocarcinoma in five of the six cases (Case 1, 2, 3, 4, and 6), while the remaining case involved papillary adenocarcinoma (Case 5). Although all cases more or less showed lymph-vascular involvement, lymphatic involvement was prominent. Case 1 and 2 involved clinically proven and denied pulmonary hypertension, respectively.

ISSN: 1746-1596