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Table 3 Results of the immunohistochemical analyses of the proliferation markers

From: Evaluation of the proliferation markers Ki-67/MIB-1, mitosin, survivin, pHH3, and DNA topoisomerase IIα in human anaplastic astrocytomas - an immunohistochemical study

Case no. Mitoses/10HPF Mitotic index Ki-67
/MIB-1
PHH3 mitoses
/10HPF
PHH3 index TIIα Survivin Mitosin
1 N.D.1 N.D. 6.8 1 0.5 1.8 2 2.4
2 0 0 3.5 1 1.7 2.5 2.7 8.5
3 15 0.9 6.8 19 0.9 10.8 5.3 3.4
4 1 0.6 9.2 18 0.9 7.9 7.5 8.6
5 0 0 19.0 6 2.2 0 5.8 3.6
6 2 0.4 9.2 2 0.6 2 3.4 3.1
7 0 0 1.0 0 0.0 0.8 0.3 0
8 1 0.6 7.9 1 0.8 2.7 3.3 3.5
9 0 0 5.0 1 0.2 0 2.4 2.5
10 0 0 2.1 3 0.6 0 1.9 1.8
11 N.D. N.D. 6.4 10 1.3 25 3.7 1.5
12 0 0 4.2 4 1.0 4 2.7 1.9
13 N.D. N.D. 4.4 4 0.6 1.8 1.2 1.1
14 N.D. N.D. 8.5 8 0.8 5 2.6 3.4
15 6 0.5 22.2 9 1.1 8.2 6 3.8
16 N.D. N.D. 8.6 1 0.5 6.1 2.5 8
17 1 0.7 N.D. N.D. N.D. 4.5 3.8 2.9
18 N.D. N.D. 15.0 5 1.9 6 4.4 2.7
19 0 0 20.0 2 0.4 5.4 2.3 1.4
20 N.D. N.D. 3.2 1 0.1 1.4 1.5 N.D.
21 N.D. N.D. 16.4 30 1.1 6.9 3.5 4.5
22 2 0.5 4.0 5 0.8 3.7 3.5 1.2
23 1 0.8 12.9 15 2.0 0 6.1 2.7
24 N.D. N.D. 4.9 16 1.5 2 2 2
25 0 0 16.5 24 1.7 11 8.9 5.1
26 0 0 10.2 19 0.6 6.3 2.6 N.D.
27 13 0.7 21.0 37 2.7 13.5 9.6 9.5
Median 0.5 0.2 8.2 5 0.8 4 3.3 2.9
Minimum 0 0 1 0 0 0 0.3 0
Maximum 15 0.9 22.2 37 2.7 25 9.6 9.5
Mean 2.3 0.3 9.6 9.3 1.0 5.2 3.8 3.6
Std. deviation 4.5 0.3 6.3 10.0 0.7 5.4 2.3 2.5
Variance 20.2 0.1 39.6 100.2 0.5 28.9 5.2 6.4
  1. 1N.D. = No Data