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Table 3 Relationship analysis among XIAP/Smac immunoscore, apoptosis index, and clinicopathologic variables

From: X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

  n* XIAP Pvalue Smac Pvalue AI Pvalue
Age        
<50 49 2.3 ± 0.8   0.5 ± 0.6   1.3 ± 1.0  
≥50 53 2.4 ± 0.8 0.586 0.3 ± 0.5 0.124 1.3 ± 1.1 0.903
Size        
≤5 cm 77 2.4 ± 0.8   0.4 ± 0.6   1.3 ± 1.1  
>5 cm 25 2.2 ± 0.9 0.386 0.4 ± 0.7 0.880 1.4 ± 1.0 0.849
LN status        
N0 39 2.4 ± 0.8   0.4 ± 0.6   1.2 ± 0.8  
N1-3 63 2.4 ± 0.8 0.969 0.4 ± 0.6 0.958 1.4 ± 1.2 0.282
Grade        
I 25 2.5 ± 0.7   0.5 ± 0.6   1.6 ± 1.4  
II-III 77 2.3 ± 0.8 0.444 0.4 ± 0.6 0.555 1.2 ± 0.9 0.227
ER        
positive 39 2.3 ± 0.8   0.4 ± 0.6   1.2 ± 1.2  
negative 63 2.4 ± 0.8 0.376 0.4 ± 0.6 0.659 1.4 ± 1.0 0.463
PR        
positive 44 2.3 ± 0.8   0.5 ± 0.6   1.3 ± 0.8  
negative 58 2.4 ± 0.8 0.669 0.3 ± 0.6 0.319 1.4 ± 1.2 0.779
HER2        
positive 94 2.4 ± 0.8   0.4 ± 0.6   1.3 ± 0.9  
negative 8 2.2 ± 0.8 0.544 0.0 ± 0.6 <0.0001 1.8 ± 2.1 0.611
XIAP-N        
positive 44 2.6 ± 0.6   0.4 ± 0.6   1.3 ± 1.1  
negative 58 2.2 ± 0.9 0.047 0.3 ± 0.6 0.540 1.4 ± 1.0 0.630
  1. n*: number of cases. AI: apoptosis index. LN: lymph node. XIAP-C and XIAP-N denoted cytoplasmic immune staining score and nuclear labeling of XIAP, respectively. P-values (two sided) < 0.05 were highlighted in bold.