X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

Table 3 Relationship analysis among XIAP/Smac immunoscore, apoptosis index, and clinicopathologic variables

	n*	XIAP	Pvalue	Smac	Pvalue	AI	Pvalue
Age
<50	49	2.3 ± 0.8		0.5 ± 0.6		1.3 ± 1.0
≥50	53	2.4 ± 0.8	0.586	0.3 ± 0.5	0.124	1.3 ± 1.1	0.903
Size
≤5 cm	77	2.4 ± 0.8		0.4 ± 0.6		1.3 ± 1.1
>5 cm	25	2.2 ± 0.9	0.386	0.4 ± 0.7	0.880	1.4 ± 1.0	0.849
LN status
N₀	39	2.4 ± 0.8		0.4 ± 0.6		1.2 ± 0.8
N_1-3	63	2.4 ± 0.8	0.969	0.4 ± 0.6	0.958	1.4 ± 1.2	0.282
Grade
I	25	2.5 ± 0.7		0.5 ± 0.6		1.6 ± 1.4
II-III	77	2.3 ± 0.8	0.444	0.4 ± 0.6	0.555	1.2 ± 0.9	0.227
ER
positive	39	2.3 ± 0.8		0.4 ± 0.6		1.2 ± 1.2
negative	63	2.4 ± 0.8	0.376	0.4 ± 0.6	0.659	1.4 ± 1.0	0.463
PR
positive	44	2.3 ± 0.8		0.5 ± 0.6		1.3 ± 0.8
negative	58	2.4 ± 0.8	0.669	0.3 ± 0.6	0.319	1.4 ± 1.2	0.779
HER2
positive	94	2.4 ± 0.8		0.4 ± 0.6		1.3 ± 0.9
negative	8	2.2 ± 0.8	0.544	0.0 ± 0.6	<0.0001	1.8 ± 2.1	0.611
XIAP-N
positive	44	2.6 ± 0.6		0.4 ± 0.6		1.3 ± 1.1
negative	58	2.2 ± 0.9	0.047	0.3 ± 0.6	0.540	1.4 ± 1.0	0.630

n*: number of cases. AI: apoptosis index. LN: lymph node. XIAP-C and XIAP-N denoted cytoplasmic immune staining score and nuclear labeling of XIAP, respectively. P-values (two sided) < 0.05 were highlighted in bold.

ISSN: 1746-1596