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Table 4 Relationship analysis among XIAP/Smac expression, apoptosis index, clinicopathologic parameters and prognosis

From: X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

  n* P value P value RR 95%CI
   (Log rank) (Cox-reg)   Lower Upper
Age      
<50 49     
≥50 53 <0.0001 0.002 9.181 2.332~36.147
Size      
≤5 cm 77     
>5 cm 25 0.006 0.065 2.903 0.935~9.016
LN status      
N0 39     
N1-3 63 <0.0001 0.012 14.757 1.803~120.750
Grade      
I 25     
II-III 77 0.596 0.391 0.555 0.144~2.134
XIAP-C      
<2 16     
≥2 86 0.153 0.188 0.398 0.101~1.568
XIAP-N      
positive 44     
negative 58 0.039 0.043 3.027 1.033~8.869
Smac      
<2 68     
≥2 34 0.595 0.395 0.634 0.222~1.809
ER      
positive 39     
negative 63 0.965 0.774 1.181 0.379~3.681
PR      
positive 44     
negative 58 0.861 0.779 1.177 0.378~3.662
HER2      
<2 31     
≥2 71 0.182 0.082 3.522 0.853~14.538
AI      
<1.32 65     
≥1.32 37 0.648 0.658 1.244 0.474~3.264
  1. n*: number of cases. RR: relative risk. CI: confidence interval. LN: lymph node. AI: apoptosis index. XIAP-C and XIAP-N denoted cytoplasmic immune staining score and nuclear labeling of XIAP, respectively. P-values (two sided) < 0.05 were highlighted in bold.