Table 1 Patients with composite histology of atypical Burkitt's and follicular lymphoma
From: Atypical burkitt's lymphoma transforming from follicular lymphoma
Patient | This case | 1 | 2 | 3 |
|---|---|---|---|---|
Age | 58 | 77 | 52 | 44 |
Sex | M | M | F | M |
Site and stage at initial presentation | Submand LN + abd LN, ascites Stage III | Generalized LN + BM Stage IV | LN Stage III | LN + BM Stage IV |
Temporal sequence of transformation | Concomitant | Concomitant | Concomitant | Concomitant |
Histology | Composite Lymphoma | Composite follicular + Burkitt's | Composite Follicular + Burkitt's | Composite Lymphoma |
Cytogenetics at transformation | t(14;18) by PCR + MYC translocation by FISH | t(14;18) + t(8;14) | t(14;18) in follicular area t(14;18) + t(8;14) in transformed area | t(14;18) + t(8;14) |
Treatment | Chemo | Chemo | Chemo → CR | Chemo → CR |
Outcome | Primary refractory died 13 months after Dx | Primary refractory and died 4 months after diagnosis | Relapsed 3 months later with partial response to salvage chemo | CNS relapse 6 months later and died |
Reference | Â | 17 | 18 | 19 |