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Table 1 Comparison of the features of well differentiated papillary mesothelioma, mesothelioma of uncertain malignant potential and diffuse malignant mesothelioma arising in tunica vaginalis

From: Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature

  Well differentiated papillary mesothelioma Mesothelioma of uncertain malignant potential Diffuse malignant mesothelioma
Clinical Presentation Hydrocele Hydrocele (most often) or scrotal mass (rare) Hydrocele or scrotal mass with hemorrhagic fluid
Gross Single or limited number of small nodules (often pedunculated) Single or limited number of small nodules (often pedunculated) Diffuse thickening or multinodular growth (larger or irregular nodules)
Microscopic Features    
   Papillary architecture Yes (exclusive) Yes (dominant) Yes (focal or rarely dominant)
   Complex morphology (cribriform, syncitial, solid architecture) No Focal Yes
   Stromal invasion No No Yes
   Cell atypia No No (or mild) Yes
   Mitotic figures No (or exceptionally rare) No (or exceptionally rare) Yes
   Atypical mitotic figures No No Yes
   Coagulative necrosis No No (or microfocal) Yes
   Sarcomatoid growth No No Yes (if present, partial or dominant)
   Psammoma bodies No No Yes
Clinical Behaviour Indolent Indolent Aggressive