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Table 2 Clinical information, morphology, immunophenotype, EBER in situ hybridization, and TCR gene rearrangement of extranodal NK/T-cell lymphoma, nasal type of head and neck region*

From: Aberrant antigenic expression in extranodal NK/T-cell lymphoma: a multi-parameter study from Thailand

No. Age/Sex Site (s) of involvement Symptom (s) and its duration Basic morphology CD3 CD5 CD7 CD4 CD8 βF1 CD56 TIA1 GB PF CD45 CD30 EBER TCR gene Clinical course
1 74/M Nasal cavity Rhinorrhea, 1 year large (A+, N+) + - - - - - + + + + + + + I D, 3 mos
2 40/M Nasal cavity Nasal obstruction, 3 mos medium (A+, N+) p+ - - - - - - + p+ p+ - + + I D, 33 mos
3 31/M Nasal cavity Nasal obstruction, 1 mo large (A+, N+) p+ - - - - - + + + + + + + - D, 37 mos
4 37/M Nasal cavity Orbital cellulitis, and fever, 2 mos medium (A-, N+) p+ - - - - - p- + p+ + NA + + - D, 3 mos
5 41/F Nasal cavity Nasal obstruction, 1 mo small to medium (A+, N+) + - NA - - - + + p+ + + NA + - D, 3 mos
6 49/F Nasal cavity Nasal obstruction, 2 mos medium to large (A-, N+) + - + - - - + + + + + p+ + - A, 60 mos
7 43/F Nasal cavity Nasal obstruction, 2 mos medium to large (A+, N+) p+ - - p+ - - + + + + - p+ + - D, 8 mos
8 32/M Nasal cavity Nasal obstruction, 5 mos medium to large (A-, N+) + - p- - - - + + p+ p+ NA - + - D, 3 mos
9 33/M Nasal cavity Rhinorrhea, 1 mo medium (A+, N+) + - + - - - + + p- p- p+ + + - D, 4 mos
10 38/M Nasal cavity Nasal obstruction with epistaxis, 2 yrs medium (A+, N+) + - - - - - p+ + + + + + + I D, 7 mos
11 48/F Nasal and oral cavities Nasal obstruction, 1 mos medium to large (A+, N+) + p+ NA - - - p+ + p+ p+ NA - + - D, 3 mos
12 36/M Nasal cavity and nasopharynx Epistaxis with fever, 1 mo small to medium (A+, N+) + - + - - - + + p+ p- p+ - + - D, 1 mos
13 26/F Nasal cavity and nasopharynx Rhinorrhea, 2 mos medium (A+, N+) + p+ + - - - + + + + NA - + - D, 4 mos
14 42/M Nasal cavity and nasopharynx Epistaxis (HIV+), 2 mos medium to large (A-, N+) + - - p+ - - + + + + p+ p+ + - D, 18 mos
15 41/M Nasopharynx Dysphagia, 3 mos medium (A+, N-) + - - - - - p+ + + + + + + - D, 11 mos
16 44/M Nasopharynx Rhinorrhea with epistaxis, 6 mos medium to large (A+, N+) - - - - - - - + p+ - - + + - D, 2 mos
17 42/M Nasopharynx Nasal obstruction, 1 wk medium to large (A+, N+) + - + - - - + + + + p+ + + I D, 5 mos
18 57/F Oral cavity Palatal mass, 2 mos large (A+, N+) + - - - - - + + + + p+ - + - D, 4 mos
19 38/M Oral cavity Chronic oral ulcer, 3 mos medium to large (A-, N+) + - - - - - - + + p+ + p+ + - D, 3 mos
20 73/M Base of tongue and larynx Dysphagia, 2 mos medium to large (A+, N+) p+ - NA - - - + + + + p+ NA + - D, 6 mos
21 66/M Periorbital soft tissue Orbital cellulitis, 2 wks medium to large (A+, N+) - - p+ - - - + + + + p+ + + - D, 3 mos
22 56/M Periorbital soft tissue Blurred vision and headache, 2 mos medium to large (A+, N+) + - - p+ - - + + p+ p+ + p+ + - D, 10 mos
  1. * Please see the abbreviations below
  2. For "basic morphology": Large: predominantly (>75%) large cells; Medium to large: mixture of medium-sized to large cells (≥25% each); Medium: predominantly (>75%) medium-sized cells; Small to medium: mixture of small to medium-sized cells (≥25% each); A+: presence of angioinvasion; A-: absence of angioinvasion; N+: presence of tissue necrosis; N-: absence of tissue necrosis
  3. For immunophenotype: GB: granzyme B; PF: perforin; + (mostly positive): positive on lymphoma cells >50%; p+ (partially positive): 10-50% positive; p- (probably negative): <10% staining; - (negative): clearly negative; NA: not available
  4. For TCR gene (PCR -based TCR gene rearrangement analysis); - (negative): no clonal band on polyacrylamide gel electrophoresis and no dominant peak on fluorescence capillary electrophoresis; I: inadequate DNA quality for PCR
  5. For clinical course: A: alive; D: death