Figure 2
From: Cardiac beriberi: morphological findings in two fatal cases
Myocardial findings in case 2. (A) Colliquative myocytolysis. Perinuclear disappearance of myofibrils with intramyocardial edema resulting in an empty sarcolemmal tube seen in transverse sections. Note the absence of any type of cellular reaction. (B) Contraction band necrosis: intense hypereosinophilia of the hypercontracted myocardial cells with rhexis of the myofibrillar apparatus into cross-fiber, anomalous, and irregular or pathological bands. The latter are formed by segments of hypercontracted sarcomeres with scalloped sarcolemma. (C) Confocal laser microscopy: CD68 showed a strong reaction in the heart where intense hypereosinophilia of the hypercontracted myocardial cells with rhexis of the myofibrillar apparatus into cross-fiber, anomalous, and irregular or pathological bands is described. (D) Confocal laser microscopy: myocyte nuclei labelled by TUNEL assay (apoptosis) revealed an intensive, wide, positive reaction (green nuclei).