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Table 3 Concordance of HER2 immunohistochemistry maximum TMA score by visual evaluation and digital analysis

From: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays

  VE2max HER2 score
VE1max HER2 score 0/1+ 2+ 3+ Total
   0/1+ 129 7 0 136
   2+ 0 7 1 8
   3+ 0 1 16 17
  DAmax HER2 score
VE1max HER2 score 0/1+ 2+ 3+ Total
   0/1+ 122 14 0 136
   2+ 0 5 3 8
   3+ 0 0 17 17
  DAmax HER2 score
VE2max HER2 score 0/1+ 2+ 3+ Total
   0/1+ 121 8 0 129
   2+ 1 11 3 15
   3+ 0 0 17 17
  1. The concordance per patient is based on maximum TMA spot HER2 score value: VE1max and VE2max - first and second visual evaluation by the pathologist, DAmax - digital analysis score.