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Table 3 Concordance of HER2 immunohistochemistry maximum TMA score by visual evaluation and digital analysis

From: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays

 

VE2max HER2 score

VE1max HER2 score

0/1+

2+

3+

Total

   0/1+

129

7

0

136

   2+

0

7

1

8

   3+

0

1

16

17

 

DAmax HER2 score

VE1max HER2 score

0/1+

2+

3+

Total

   0/1+

122

14

0

136

   2+

0

5

3

8

   3+

0

0

17

17

 

DAmax HER2 score

VE2max HER2 score

0/1+

2+

3+

Total

   0/1+

121

8

0

129

   2+

1

11

3

15

   3+

0

0

17

17

  1. The concordance per patient is based on maximum TMA spot HER2 score value: VE1max and VE2max - first and second visual evaluation by the pathologist, DAmax - digital analysis score.