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Table 4 Proportion of HER2 FISH-positive cases in the IHC score categories by visual evaluation and digital analysis

From: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays

  HER2 FISH positive (%)
HER2 score VE1max VE2max DAmax
0/+1 8/127 (6.3) 7/120 (5.8) 5/113 (4.4)
2+ 2/8 (25.0) 2/15 (13.3) 3/19 (15.8)
3+ 14/17 (82.4) 15/17 (88.2) 16/20 (80.0)
Total 152 152 152
  1. Number and percentage (in parentheses) of FISH-positive patients in the IHC score categories by maximum TMA spot HER2 score value: VE1max and VE2max - first and second visual evaluation by the pathologist, DAmax - digital analysis score.