Figure 4

Photomicrographs of histological changes of the renal biopsy. (A) Renal biopsy illustrated small lymphocyte-like cell infiltrate in the interstitial tissue. The glomeruli showed amorphous eosinophilic material in the meangium and extending to the peripheral capillary walls leading the obliteration of segmental capillary loop. Foci of deposition were found in the interstitial and peritubular space. (HE staining×200). (B). Salmon pink staining of the glomeruli with Congo red staining.(×400). (C). Apple green birefringence was detected under polarized light (×400). (D) Uniform small lymphoid cell infiltrate in a nodular pattern around a sclerotic glomerulus. (HE staining×200). (E) The infiltrating cells in the interstitium were CD20 positive by immunohistochemistry (×200). (F) Non-branched and randomly arranged fine fibrils in a diameter of 10 nm were found in the glomerular mesangial area (×37000).