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Table 4 Correlation between grading and staging of chronic hepatitis and protein kinase R in liver tissue

From: Implication of protein kinase R Gene quantification in hepatitis C Virus Genotype 4 induced Hepatocarcinogenesis

 

PKR gene expression in liver

GII

(HCV-4)

GIII

(HCV-4 related HCC)

Spearman's correlation coefficient

r s

P-value

r s

P-value

HAI

0.83

0.0001

0.89

0.0001

Fibrosis

o.56

0.004

0.84

0.0001

  1. A significant positive correlation is obvious in which higher HAI and fibrosis scores are associated with high rate of PKR gene expression.
  2. GII (HCV-4): group II with hepatitis C virus genotype 4; GIII (HCV-4 related HCC): group III with hepatitis C virus genotype 4 related hepatocellular carcinoma; HAI: histological activity.
  3. Index; PKR: protein kinase R.