Diagnostic Pathology

Table 4 Immunohistochemical staining scores of serous and mucinous ovarian tumors as benign, borderline, and malignant

From: Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

	Serous			Mucinous
	Benign	Borderline	Malignant	Benign	Borderline	Malignant
	(n = 13)	(n = 9)	(n = 24)	(n = 12)	(n = 7)	(n = 3)
p53*	0^a	0 (0–1)^b	4 (0–4)^b	0	0	1 (0–4)^c
p21*	3 (0–4)^d,e	4 (1–4)^f	4 (1–4)^f	0.5 (0–4)	2 (1–4)	2 (2–4)
bax**	0 (0–2)	1 (0–4)	1 (0–6)	0 (0–1)^g	0 (0–4)	1 (0–3)
bcl-2**	0 (0–2)	0 (0–4)	0 (0–4)	0	0	0
c-kit**	1 (0–6)	0 (0–4)	0.5 (0–12)	0 (0–4)	0 (0–1)	0
Telomerase*	0 (0–3)	0 (0–2)	0 (0–2)	0	0 (0–3)	1 (0–3)
Metallothionein**	2 (0–6)	4 (1–6)ⁱ	6 (0–12)ⁱ	0 (0–9)	2 (0–12)^j	2 (1–6)

Data were presented as median (min-max). * Nuclear staining score. ** Quick score.
^a,e,gP < 0.05 vs. borderline and malignant serous.
^b,fP < 0.05 vs. benign and borderline mucinous.
^c,iP < 0.05 vs. benign serous and benign mucinous.
^d,jP < 0.05 vs. benign mucinous.

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ISSN: 1746-1596

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