Table 1 Immunohistochemical staining of Langerhans cell sarcoma
From: Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression
Marker | Langerhans cell sarcoma in our case | Typical immunophenotype of tumors derived from Langerhans cells |
|---|---|---|
CD1a | + | + |
Langerin | + | + |
S100 | + | + |
CD4 | + | + |
CD3 | 30-40% + cytoplasm | - |
p53 | + | +/− |
CD30 | 30-40% + | NK |
BCL2 | + | + |
Ki-67 | >50% | 0-25% |
CD5 | - | - |
CD8 | - | - |
CD10 | - | - |
CD20 | - | - |
CD23 | - | - |
CD56 | - | - |
BCL6 | - | - |
MUM-1 | - | - |
Cyclin D1 | - | - |
CD68 | - | +/− |
CD163 | - | NK |
ALK | - | - |