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Table 3 Univariate analysis of pathological variables and two automated techniques (CD3 + cell counts from TMA and LQLI) for disease-free survival

From: Linear quantification of lymphoid infiltration of the tumor margin: a reproducible method, developed with colorectal cancer tissues, for assessing a highly variable prognostic factor

Clinical & pathological variables

No.

%

3-yr DFS

5-yr DFS

HR

95% CI

P

TNM stage

    

2.97

1.29-6.81

0.009

II

78

67

91

87

   

III

39

33

74

67

   

Metastatic LNR ratio

    

4.49

1.81-11.13

<0.001

≤0.2

102

87

89

85

   

>0.2

15

13

58

58

   

Vascular embolism

    

4.05

1.75-9.37

0.001

Yes

41

35

73

66

   

No

76

65

92

89

   

Perineural invasion

    

2.96

1.28-6.85

0.01

Yes

25

21

67

60

   

No

92

79

90

86

   

MSI status

    

1.36

0.89-2.34

0.11

MSI -

107

91

84

80

   

MSI +

10

9

No event

No event

   

Lymphocyte density (CD3+ cells/mm²) with TMA

    

2.54

1.1-6.4

0.04

High [CD3+]

50

43

92

90

   

Low [CD3+]

67

57

80

74

   

CD3+ LQLI pattern

    

4.75

2.33-9.68

<0.0001

Pattern 1

24

20

96

96

   

Pattern 2

71

61

90

86

   

Pattern 3

22

19

59

45

   

CD45R0+ LQLI pattern

       

Pattern 1

23

19

96

96

3.85

1.09-7.77

<0.001

Pattern 2

70

60

90

85

   

Pattern 3

24

21

62

44

   
  1. LNR lymph node ratio, HR hazard ratio, CI confidence interval, DFS disease-free survival.