Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies

Yu, Liwa; Chen, Jianqiu

doi:10.1186/1746-1596-7-171

Table 1 The main characteristics of these studies and the distribution of MTHFR Ala222Val genotypes and alleles among cases and controls

From: Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies

First author [Inference]	Year	Ethnicity		Cases			Controls		HWE
First author [Inference]	Year	Ethnicity	CC	CT	TT	CC	CT	TT	HWE
Sharp[8]	2002	Caucasian	30	19	5	25	21	11	0.103
Campbell[9]	2002	Caucasian	140	162	33	118	92	23	0.420
Semenza[10]	2003	Caucasian	42	58	5	112	111	24	0.643
Langsenlehner[11]	2003	Caucasian	208	222	64	215	215	65	0.333
Ergul[12]	2003	Caucasian	60	41	17	94	87	12	0.164
Shrubsole[13]	2004	Asian	374	555	183	387	577	196	0.442
Fo¨rsti[14]	2004	Caucasian	134	81	8	181	104	13	0.689
Lee[15]	2004	Asian	58	96	32	50	80	17	0.076
Grieu[16]	2004	Caucasian	166	141	27	242	259	50	0.100
Lin[17]	2004	Asian	43	38	7	173	145	24	0.389
Qi[18]	2004	Asian	42	104	71	59	105	54	0.593
Chen[19]	2005	Mixed	398	476	189	440	509	155	0.689
Kalemi[20]	2005	Caucasian	19	16	7	23	20	8	0.313
Deligezer[21]	2005	Caucasian	98	68	23	128	83	12	0.759
Justenhoven[22]	2005	Caucasian	249	247	61	261	279	93	0.193
Chou[23]	2006	Asian	73	51	18	132	120	33	0.475
Kalyankumar[24]	2006	Caucasian	45	37	6	61	31	3	0.693
Xu[25]	2007	Mixed	398	476	189	440	509	155	0.689
Hekim[26]	2007	Caucasian	22	16	2	38	26	4	0.872
Macis[27]	2007	Caucasian	14	20	12	28	41	11	0.511
Yu[28]	2007	Asian	56	54	9	225	170	25	0.336
Reljic[29]	2007	Caucasian	40	44	9	27	34	4	0.114
Inoue[30]	2008	Asian	239	120	21	393	226	43	0.178
Kotsopoulos[31]	2008	Caucasian	383	421	140	252	341	87	0.087
Suzuki[32]	2008	Asian	150	220	84	338	425	146	0.522
Cheng[33]	2008	Asian	185	133	31	268	221	41	0.624
Langsenlehner[34]	2008	Caucasian	51	43	11	40	48	17	0.685
Ericson[35]	2009	Caucasian	255	235	50	531	452	91	0.707
Gao[36]	2009	Asian	202	305	117	235	301	88	0.592
Ma[37]	2009	Asian	124	183	81	115	188	84	0.663
Platek[38]	2009	Mixed	429	446	119	788	795	219	0.398
Henrı′quez-Herna′ndez[39]	2009	Caucasian	52	65	18	107	138	47	0.823
Cam[40]	2009	Caucasian	48	49	13	47	42	6	0.398
Maruti[41]	2009	Mixed	133	139	46	301	284	62	0.672
Ma[42]	2009	Mixed	225	188	45	222	187	49	0.309
Li[43]	2009	Asian	38	17	10	90	50	3	0.187
Yuan[44]	2009	Asian	16	35	29	32	35	13	0.516
Jin[45]	2009	Asian	18	20	3	49	41	10	0.742
Bentley[46]	2010	Caucasian	346	402	191	429	529	205	0.060
Alshatwi[47]	2010	Asian	34	50	16	36	49	15	0.800
Sangrajrang[48]	2010	Asian	410	144	9	366	110	11	0.427
Weiner[49]	2010	Caucasian	399	364	74	386	326	66	0.808
Prasad[50]	2011	Asian	124	5	1	116	8	1	0.062
Batschauer[51]	2011	Caucasian	27	34	7	42	34	9	0.593
Mohammad[52]	2011	Asian	168	53	1	198	37	0	0.190
Naushad[53]	2011	Asian	185	56	3	205	39	0	0.175
Cerne[54]	2011	Caucasian	222	238	62	108	124	37	0.882
Akram[55]	2012	Caucasian	65	25	20	55	45	10	0.855
Barbosa[56]	2012	Mixed	76	83	17	87	70	19	0.389
Lajin[57]	2012	Caucasian	44	52	23	65	48	13	0.359
Jakubowska[58]	2012	Mixed	2032	2166	580	1447	1481	422	0.156

HWE Hardy–Weinberg equilibrium.

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ISSN: 1746-1596

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