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Table 2 Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis

From: Association of MHTFR Ala222Val (rs1801133) polymorphism and breast cancer susceptibility: An update meta-analysis based on 51 research studies

Variables

No. of studies

 

Ala/Ala vs Val/Val

  

Ala/Ala vs Ala/Val

  

Ala/Val vs Val/Val

 

OR (95% CI)

Ph

P

OR (95% CI)

Ph

P

OR (95% CI)

Ph

P

Total

51

0.870(0.789 0.958)

0.001

0.005

0.969(0.923 1.016)

0.206

0.191

0.895(0.821 0.976)

0.021

0.012

Asian

19

0.787(0.645 0.961)

0.017

0.019

0.929(0.843 1.023)

0.212

0.132

0.865(0.753 0.993)

0.300

0.039

Caucasian

25

0.869(0.741 1.020)

0.040

0.319

1.004(0.921 1.095)

0.137

0.926

0.910(0.778 1.064)

0.031

0.238

Mixed

7

0.925(0.793 1.079)

0.050

0.087

0.958(0.898 1.022)

0.946

0.191

0.912(0.778 1.068)

0.050

0.253

Variables

No. of studies

Ala/Val + Ala/Val vs Val/Va (dominant)

Ala/Ala vs Ala/Val + Val/Va (recessive)

Ala allele vs Val allele

OR (95% CI)

P h

P

OR (95% CI)

P h

P

OR (95% CI)

P h

P

Total

51

0.882(0.808 0.963)

0.004

0.005

0.944(0.898 0.993)

0.055

0.026

0.935(0.887 0.986)

0.000

0.013

Asian

19

0.826(0.703 0.972)

0.075

0.021

0.890(0.799 0.991)

0.043

0.034

0.877(0.801 0.960)

0.003

0.008

Caucasian

25

0.916(0.790 1.063)

0.030

0.247

0.985(0.908 1.069)

0.141

0.720

0.883(0.805 0.968)

0.052

0.359

Mixed

7

0.888(0.758 1.041)

0.029

0.144

0.946(0.890 1.006)

0.773

0.076

0.957(0.838 1.094)

0.000

0.523

  1. Ph: P value of Q-test for heterogeneity test.