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Table 2 Association of LMP1 and LMP2A expression with clinical characteristics and selected biological markers of ENKTL

From: LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)

Groups

No.

LMP1 expression

p value

LMP2A expression

p value

  

Positive

Negative

 

Positive

Negative

 

Gender

       

 Male

13

7

6

0.687

4

9

0.029*

 Female

3

2

1

 

3

0

 

Age (years)

       

 ≤40 y

5

3

2

0.838

3

2

0.377

 >40 y

11

6

5

 

4

7

 

Ann Arbor Stage

       

 I-II

14

7

7

0.182

6

8

0.849

 III-IV

2

2

0

 

1

1

 

LDH level

       

 High

5

3

2

0.838

2

3

0.838

 Normal

11

6

5

 

5

6

 

B symptoms

       

 Positive

8

7

1

0.012*

4

4

0.614

 Negative

8

2

6

 

3

5

 

IPI

       

 Low/Low-intermediate

11

5

6

0.197

4

7

0.377

 High-intermediate/High

5

4

1

 

3

2

 

Response to treatment

       

 Complete remission

7

4

3

0.493

4

3

0.319

 Partial remission

8

5

3

 

2

6

 

 No response

1

0

1

 

1

0

 

Prognosis

       

 Live

7

2

5

0.049*

1

6

0.036*

 Dead

9

7

2

 

6

3

 
  1. LDH: lactate dehydrogenase; IPI: international prognostic index; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; * P < 0.05.