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Table 2 Association of LMP1 and LMP2A expression with clinical characteristics and selected biological markers of ENKTL

From: LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)

Groups No. LMP1 expression p value LMP2A expression p value
   Positive Negative   Positive Negative  
Gender        
 Male 13 7 6 0.687 4 9 0.029*
 Female 3 2 1   3 0  
Age (years)        
 ≤40 y 5 3 2 0.838 3 2 0.377
 >40 y 11 6 5   4 7  
Ann Arbor Stage        
 I-II 14 7 7 0.182 6 8 0.849
 III-IV 2 2 0   1 1  
LDH level        
 High 5 3 2 0.838 2 3 0.838
 Normal 11 6 5   5 6  
B symptoms        
 Positive 8 7 1 0.012* 4 4 0.614
 Negative 8 2 6   3 5  
IPI        
 Low/Low-intermediate 11 5 6 0.197 4 7 0.377
 High-intermediate/High 5 4 1   3 2  
Response to treatment        
 Complete remission 7 4 3 0.493 4 3 0.319
 Partial remission 8 5 3   2 6  
 No response 1 0 1   1 0  
Prognosis        
 Live 7 2 5 0.049* 1 6 0.036*
 Dead 9 7 2   6 3  
  1. LDH: lactate dehydrogenase; IPI: international prognostic index; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; * P < 0.05.