Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma

Diagnostic Pathology

Table 2 Clinicopathological characteristics of patients with SMPC

	all	%	SMPC				P value
			(-)	%	(+)	%
No.	559		540	97	19	3
Age
Median	67		67		67		0.219*
Range	23-87		23-87		40-76
Gender
Female	288	52	282	52	6	32	0.077**
Male	271	48	258	48	13	68
Smoking status
Nonsmoker	284	51	276	51	8	42	0.596**
Smoker	275	49	264	49	11	58
BI Average	369		364		502
Tumor size
Average(mm)	25		25		35
Range(mm)	5-140		5-140		15-75
< 30 mm	396	71	388	72	9	47	< 0.001*
≥ 30 mm	163	29	152	28	10	53
Pathological stage
IA	363	65	360	67	4	21	< 0.001**
IB	95	17	88	16	6	32
IIA	36	6	31	6	5	26
IIB	13	2	13	2	0	0
IIIA	42	8	39	7	3	16
≥ IIIB	10	2	9	2	1	5
Lymph node metastasis
NX	69	12	68	13	1	5
N0	420	75	409	75	11	58	0.002**
≥ N1	70	13	63	12	7	21
Pleural invasion
Negative	452	80	446	83	6	32	< 0.001**
Positive	107	20	94	17	13	68
Lymphatic invasion
Negative	466	83	461	85	5	26	< 0.001**
Positive	93	17	79	15	14	74
Vascular invasion
Negative	427	76	422	78	5	26	< 0.001**
Positive	132	24	118	22	14	74

* Mann-Whitney's U test
** Chi-square for independence test
No., number of patients; BI, Brinkman index = (number of cigarettes per day) × (duration of years); SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component

ISSN: 1746-1596