Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma

Diagnostic Pathology

Table 3 Impact of potential prognostic factors on DFS of patients of lung adenocarcinoma in all stage by univariate and multivariate analysis

	No.	%	Univariate analysis	Multivariate analysis
			P value	Hazard ratio	95% CI	P value
Total	559
Age
< 65	213	38	0.388	1.000
≥ 65	346	62		1.933	0.849-4.402	0.116
Gender
Female	288	52	0.768	1.000
Male	271	48		0.807	0.232-2.803	0.735
Smoking status
Non-smoker	284	49	0.560	1.000
Smoker	275	51		1.164	0.342-3.956	0.808
Tumor size
< 30 mm	396	71	0.059	1.000
≥ 30 mm	163	29		0.819	0.338-1.985	0.658
Pathological stage
I	458	82	<0.001	1.000
II, III, IV	101	18		2.768	1.113-6.884	0.028
Pleural invasion
Negative	452	81	<0.001	1.000
Positive	107	19		0.848	0.345-2.083	0.719
Lymphatic invasion
Negative	466	83	<0.001	1.000
Positive	93	17		3.430	1.363-8.634	0.009
Vascular invasion
Negative	427	76	<0.001	1.000
Positive	132	24		3.309	1.312-8.350	0.011
SMPC
Negative	540	97	<0.001	1.000
Positive	19	3		1.871	0.528-6.630	0.332
AMPC
Negative	460	83	0.045	1.000
Positive	99	17		1.132	0.450-2.845	0.792

DFS, disease free survival; No., number of patients; SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; CI, confidence interval.

ISSN: 1746-1596