Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma

Diagnostic Pathology

Table 4 Impact of potential prognostic factors on DFS of patients of lung adenocarcinoma in p-stage I by univariate and multivariate analysis

	No.	%	Univariate Analysis	Multivariate analysis
			P value	Hazard ratio	95% CI	P value
Total	458
Age
< 65	172	38	0.394	1.000
≥ 65	286	62		2.191	0.474-10.131	0.316
Gender
Female	249	54	0.063	1.000
Male	209	46		0.157	0.014-1.787	0.136
Smoking status
Non-smoker	248	54	0.204	1.000
Smoker	210	46		0.768	0.117-5.052	0.784
Tumor size
< 30 mm	358	78	0.264	1.000
≥ 30 mm	100	22		0.304	0.037-2.504	0.268
Pleural invasion
Negative	402	88	< 0.001	1.000
Positive	56	12		1.519	0.328-7.040	0.593
Lymphatic invasion
Negative	415	91	< 0.001	1.000
Positive	43	9		5.016	1.295-19.434	0.020
Vascular invasion
Negative	390	85	< 0.001	1.000
Positive	68	15		4.494	1.006-20.081	0.049
SMPC
Negative	448	98	< 0.001	1.000
Positive	10	2		9.028	1.164-70.031	0.035
AMPC
Negative	389	98	0.023	1.000
Positive	69	2		1.825	0.378-8.808	0.454

DFS, disease free survival; No., number of patients; SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; CI, confidence interval.

ISSN: 1746-1596