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Table 1 hTERC Amplification According to Histopathologic Evaluation

From: Human telomerase RNA component (hTERC) gene amplification detected by FISH in precancerous lesions and carcinoma of the larynx

Laryngeal lesions

Cases, no.

hTERC+, no. (%)

Abnormal cells, no. (%)*

Proportion of amplification types, % of cases

    

2:3

2:4

2:5

3:3

4:4

5:5

6:6

Others 3:4,3:5, 4:5 etc.

Normal epithelium

14

0(0.0)

22(1.6)

100

       

Mild dysplasia

15

2 (13.3)

68 (4.5)

85.3

14.7

      

Moderate dysplasia

18

13 (72.2)

409 (22.7)

47.6

39.8

1.5

4.8

3.6

  

2.7

Sereve dysplasia

16

13 (81.3)

506(31.6)

38.6

34.6

2.7

9.8

7.6

2.8

0.4

3.5

Carcinoma in situ

9

9(100.0)

353(39.2)

28.1

24.6

3.8

17.8

14.5

6.4

1.6

3.2

Invasive carcinoma

21

21(100.0)

988 (47.0)

14.2

12.3

6.2

21.6

24.7

15.4

2.3

3.3

  1. *Number of abnormal cells (% abnormal cells out of total cells examined, and 100 cells were observed in each case)
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